Sacubitril sodium|CAS 149690-05-1|DC Chemicals

Cas No.:	149690-05-1
Chemical Name:	Sacubitril sodium
Synonyms:	Sacubitril sodium; AHU377; AHU 377; AHU-377; LCZ696. Entresto.
SMILES:	O=C([O-])CCC(N[C@@H](C[C@@H](C)C(OCC)=O)CC1=CC=C(C2=CC=CC=C2)C=C1)=O.[Na+]
Formula:	C₂₄H₂₈NNaO₅
M.Wt:	433.480
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Sacubitril, also known as AHU377, is angiotensin receptor neprilysin inhibitor being studied for use in combination with valsartan for heart failure. Sacubitril is a prodrug that is activated to LBQ657 by de-ethylation via esterases. LBQ657 inhibits the enzyme neprilysin, which is responsible for the degradation of atrial and brain natriuretic peptide, two blood pressure lowering peptides that work mainly by reducing blood volume.

MSDS

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MSDS_14547_DC32235_149690-05-1

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