Sodium-Channel-inhibitor-1|cas 1198117-23-5|DC Chemicals|Price|Buy

Cas No.:	1198117-23-5
SMILES:	O=C(C1N(CCC2=NC=CC=C2)C(C3=C1C(F)=CC=C3)=O)NCC4=CC=C(OC(F)(F)F)C=C4
Formula:	C₂₄H₁₉F₄N₃O₃
M.Wt:	473.42
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

IC50 Value: 0.16 uM ( Na v1.7, V hold-90mV); 0.41 uM (Na v1.7, V hold-90mV) Sodium Channel inhibitor1, one of 3-Oxoisoindoline-1-carboxamides, is a novel and selective voltage-gated sodium channel For pain treatment. Sodium Channel inhibitor1 demonstrated concentration-dependent e?cacy in preclinical behavioral pain models.For the detailed information of Sodium-Channel-inhibitor-1, the solubility of Sodium-Channel-inhibitor-1 in water, the solubility of Sodium-Channel-inhibitor-1 in DMSO, the solubility of Sodium-Channel-inhibitor-1 in PBS buffer, the animal experiment (test) of Sodium-Channel-inhibitor-1, the cell expriment (test) of Sodium-Channel-inhibitor-1, the in vivo, in vitro and clinical trial test of Sodium-Channel-inhibitor-1, the EC50, IC50,and Affinity of Sodium-Channel-inhibitor-1, Please contact DC Chemicals.

Cat. No.	Product name	Field of application
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DC46234	Phrixotoxin 3 TFA	Phrixotoxin 3 TFA is a potent blocker of voltage-gated sodium channels, with IC50s of 0.6, 42, 72, 288, 610 nM for NaV1.2, NaV1.3, NaV1.4, NaV1.1 and NaV1.5, respectively. Phrixotoxin 3 TFA modulates voltage-gated sodium channels with properties similar to those of typical gating-modifier toxins, both by causing a depolarizing shift in gating kinetics and by blocking the inward component of the sodium current.
DC46036	GX-201	GX-201 is a selective NaV1.7 inhibitor, with an IC50 of <3.2 nM for hNaV1.7.
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