TAPI-0 (TNF-α processing inhibitor-0)

Cas No.:	143457-40-3
Chemical Name:	N-(R)-[2-(HYDROXYAMINOCARBONYL)METHYL]-4-METHYLPENTANOYL-L-NAPHTHYLALANYL-L-ALANINE AMIDE
Synonyms:	TAPI0,TAPI 0
SMILES:	C[C@@H](C(NC1=C2C=CC=CC2=CC=C1)=O)NC([C@H](C)NC([C@@H](CC(NO)=O)CC(C)C)=O)=O
Formula:	C24H32N4O5
M.Wt:	456.53
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

TAPI-0 is an inhibitor of TACE (IC50 = 50-100 nM) as well as other matrix and membrane metalloproteases.For example, it inhibits meprin (Ki value for human meprin α is 2.2 μM).4 Through these actions TAPI-0 blocks the maturation of cytokines, soluble cytokine receptors, and other proteins that require the action of proteases. For the detailed information of TAPI-0 (TNF-α processing inhibitor-0), the solubility of TAPI-0 (TNF-α processing inhibitor-0) in water, the solubility of TAPI-0 (TNF-α processing inhibitor-0) in DMSO, the solubility of TAPI-0 (TNF-α processing inhibitor-0) in PBS buffer, the animal experiment (test) of TAPI-0 (TNF-α processing inhibitor-0), the cell expriment (test) of TAPI-0 (TNF-α processing inhibitor-0), the in vivo, in vitro and clinical trial test of TAPI-0 (TNF-α processing inhibitor-0), the EC50, IC50,and affinity,of TAPI-0 (TNF-α processing inhibitor-0), For the detailed information of TAPI-0 (TNF-α processing inhibitor-0), the solubility of TAPI-0 (TNF-α processing inhibitor-0) in water, the solubility of TAPI-0 (TNF-α processing inhibitor-0) in DMSO, the solubility of TAPI-0 (TNF-α processing inhibitor-0) in PBS buffer, the animal experiment (test) of TAPI-0 (TNF-α processing inhibitor-0), the cell expriment (test) of TAPI-0 (TNF-α processing inhibitor-0), the in vivo, in vitro and clinical trial test of TAPI-0 (TNF-α processing inhibitor-0), the EC50, IC50,and affinity,of TAPI-0 (TNF-α processing inhibitor-0), Please contact DC Chemicals.