TCPOBOP|CAS 76150-91-9|DC Chemicals

Cas No.:	76150-91-9
Chemical Name:	1,4-bis((3,5-dichloropyridin-2-yl)oxy)benzene
Synonyms:	TCPOBOP
SMILES:	ClC1=CN=C(OC2=CC=C(OC3=NC=C(Cl)C=C3Cl)C=C2)C(Cl)=C1
Formula:	C₁₆H₈Cl₄N₂O₂
M.Wt:	402.052
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:	TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss[1]. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins[2].
Target:	Bcl-2
In Vivo:	TCPOBOP (oral; 3 mg/kg; 1-5 days) remarkable increases Liver weight to body weight in LW/BW ratio at 48 hours[1]. Animal Model: METfl/fl: Tam-Cre+/+ mice with a targeted deletion for exon 16 with MET KO[1] Dosage: 3 mg/kg Administration: Oral; 1, 2, 5 days Result: Increased Liver weight to body weight.
References:	[1]. Bhushan B, et al. TCPOBOP-Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling. Hepatology. 2019 Apr;69(4):1702-1718. [2]. Baskin-Bey ES, et al. Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Hepatology. 2006 Jul;44(1):252-62.

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