TG8-69 |CAS|DC Chemicals

Cas No.:
Chemical Name:	N-(2-(2-methyl-1H-indol-3-yl)ethyl)-4-(1H-tetrazol-5-yl)benzamide
SMILES:	C(NCCC1C2=C(NC=1C)C=CC=C2)(=O)C1=CC=C(C2NN=NN=2)C=C1
Formula:	C₁₉H₁₈N₆O
M.Wt:	346.394
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

TG8-69 is a peripherally restricted, highly potent, selective, aqueous-soluble EP2 antagonist with Kb of 48.5 nM; inhibits PGE2 induced EP2 receptor activation in a concentration-dependent manner in cAMP mediated TR-FRET based functional EP2 assay, inhibits the binding of radiolabeled H3-PGE2 to EP2 receptors with Ki of 135 nM; displays >1000-fold selectivity ober other Gαs-coupled prostanoid receptors, DP1, EP4, and IP; demonstrates anti-inflammatory properties.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101

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