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TH-34

  Cat. No.:  DC12487   Featured
Chemical Structure
2196203-96-8
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More than 5000 active chemicals with high quality for research!
Field of application
TH34 is a potent HDAC6/8/10 inhibitor, induceing DNA damage-mediated cell death in human high-grade neuroblastoma cell lines.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2196203-96-8
Chemical Name: 3-(benzylamino)-N-hydroxy-4-methylbenzamide
Synonyms: TH34,TH 34
SMILES: O=C(NO)C1=CC=C(C)C(NCC2=CC=CC=C2)=C1
Formula: C15H16N2O2
M.Wt: 256.12
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: TH34, an HDAC6/8/10 inhibitor with IC50s of 4.6 μM, 1.9 μM, and 7.7 μM respectively, shows high selectivity over HDAC1/2/3[1].
Target: HDAC6:4.6 μM (IC50) HDAC8:1.9 μM (IC50) HDAC10:7.7 μM (IC50)
In Vitro: TH34 induces caspase-dependent programmed cell death and cell cycle arrest in neuroblastoma cells[1].
References: [1]. Kolbinger FR, et al. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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