Cas No.: | 957772-01-9 |
Chemical Name: | 1-(1,3-dihydroxy-2-(hydroxymethyl)propan-2-yl)-3-(4-(4-hydroxy-2-methyl-5-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)benzyl)phenethyl)urea |
Synonyms: | TP-0438836;TP 0438836 |
SMILES: | N(C(CO)(CO)CO)C(NCCC1=CC=C(CC2=CC([C@H]3O[C@@H](CO)[C@H](O)[C@@H](O)[C@@H]3O)=C(O)C=C2C)C=C1)=O |
Formula: | C27H38N2O10 |
M.Wt: | 550.605 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | TP0438836 is a potent, low-absorbable sodium-dependent glucose cotransporter (SGLT) inhibitor with IC50 of 28 nM/7 nM for hSGLT1 and hSGLT2, respectively; shows a desirable PK profile in Sprague-Dawley (SD) rats and a favorable glucose-lowering effect in diabetic rats. |