EGFR-IN-7(TQB3804 )|CAS 2267329-76-8|DC Chemicals

Cas No.:	2267329-76-8
Chemical Name:	Egfr-IN-7
Synonyms:	s6698;BCP34208;TQB3804 (EGFR-IN-7);EGFR-IN-7;TQB-3804 ;TQB 3804
SMILES:	BrC1=CN=C(N=C1NC1C=CC2C(C=1P(C)(C)=O)=NC=CN=2)NC1=C(C=C(C(C)=C1)N1CCC(CC1)N1CCN(C)CC1)OC
Formula:	C₃₂H₄₁BrN₉O₂P
M.Wt:	694.604805707932
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication:	[1]. Aryl-phosphorus-oxygen compound as egfr kinase inhibitor.

Description:	EGFR-IN-7 (compound 34) is a selective and potent EGFR kinase inhibitor extracted from patent WO2019015655A1, has IC50s of 7.92 nM and 0.218 nM for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) respectively, and shows anti-tumor activity[1].
Target:	EGFR (WT):7.92 nM (IC50) EGFR (C797S/T790M/L858R):0.218 nM (IC50)
References:	[1]. Aryl-phosphorus-oxygen compound as egfr kinase inhibitor.

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Egfr-IN-7(TQB3804 )