Cas No.: | 1603845-32-4 |
Chemical Name: | TX1-85-1 |
Synonyms: | TX-85-1, ErbB3;TX1-85-1;TX-85-1;TX-85-1 ? N-(5-{1-[4-(4-Acetyl-piperazin-1-yl)-cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-phenoxy-phenyl)-acrylamide;2-Propenamide, N-[5-[1-[4-(4-acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-phenoxyphenyl]- |
SMILES: | C(NC1=CC(C2C3=C(N)N=CN=C3N(C3CCC(N4CCN(C(C)=O)CC4)CC3)N=2)=CC=C1OC1=CC=CC=C1)(=O)C=C |
Formula: | C32H36N8O3 |
M.Wt: | 580.693 |
Purity: | >98% |
Sotrage: | 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO |
Description: | TX1-85-1 is a Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling[1]. |
Target: | ErbB3:23 nM (IC50) |
References: | [1]. Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10(12):1006-12. |