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TX1-85-1

  Cat. No.:  DC12480   Featured
Chemical Structure
1603845-32-4
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More than 5000 active chemicals with high quality for research!
Field of application
TX1-85-1 is a potent, selective, ATP-competitive Her3 (ErbB3) inhibitor with IC50 of 23 nM, forms a covalent bond with Cys721 located in the ATP-binding site of Her3.
Cas No.: 1603845-32-4
Chemical Name: TX1-85-1
Synonyms: TX-85-1, ErbB3;TX1-85-1;TX-85-1;TX-85-1 ? N-(5-{1-[4-(4-Acetyl-piperazin-1-yl)-cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl}-2-phenoxy-phenyl)-acrylamide;2-Propenamide, N-[5-[1-[4-(4-acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-phenoxyphenyl]-
SMILES: C(NC1=CC(C2C3=C(N)N=CN=C3N(C3CCC(N4CCN(C(C)=O)CC4)CC3)N=2)=CC=C1OC1=CC=CC=C1)(=O)C=C
Formula: C32H36N8O3
M.Wt: 580.693
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: TX1-85-1 is a Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling[1].
Target: ErbB3:23 nM (IC50)
References: [1]. Xie T, et al. Pharmacological targeting of the pseudokinase Her3. Nat Chem Biol. 2014 Dec;10(12):1006-12.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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