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Thalidomide-NH-PEG8-Ts

  Cat. No.:  DC42432  
Chemical Structure
2488761-07-3
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More than 5000 active chemicals with high quality for research!
Field of application
Thalidomide-NH-PEG8-Ts is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and 8-unit PEG linker used in PROTAC technology, such as IDO1 PROTAC degrader.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2488761-07-3
Chemical Name: Thalidomide-NH-PEG8-Tos
Synonyms: 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[23-[[(4-methylphenyl)sulfonyl]oxy]-3,6,9,12,15,18,21-heptaoxatricos-1-yl]amino]-;Thalidomide-?NH-PEG8-OTS;Thalidomide-NH-PEG8-Tos;Pomalidomide-NH-PEG8-Tos
SMILES: C1(=O)C2=C(C(NCCOCCOCCOCCOCCOCCOCCOCCOS(C3=CC=C(C)C=C3)(=O)=O)=CC=C2)C(=O)N1C1CCC(=O)NC1=O
Formula: C36H49N3O14S
M.Wt: 779.85
Purity: >98%
Sotrage: Please store the product under the recommended conditions in the Certificate of Analysis.
MSDS
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MSDS_26039_DC42432_2488761-07-3
COA
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Cat. No. Product name Field of application
DC46474 Lenalidomide-PEG3-iodine Lenalidomide-PEG3-iodine is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a 3-unit PEG linker. Lenalidomide-PEG3-iodine can be used in the synthesis of a series of PROTACs, such as SJF620. SJF620 is a potent PROTAC BTK degrader with a DC50 of 7.9 nM.
DC46473 Lenalidomide-C9-aldehyde Lenalidomide-C9-aldehyde is a synthesized E3 ligase ligand-linker conjugate that incorporates the Lenalidomide based cereblon ligand and a linker. Lenalidomide-C9-aldehyde can be used in the synthesis of a series of PROTACs, such as INY-03-041. INY-03-041 is a potent, highly selective and PROTAC-based pan-Akt degrader. INY-03-041 inhibits Akt1, Akt2 and Akt3 with IC50s of 2.0 nM, 6.8 nM and 3.5 nM, respectively.
DC46472 (S,R,S)-AHPC-C3-NH2 TFA (S,R,S)-AHPC-C3-NH2 TFA (VH032-C3-NH2 TFA) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology. (S,R,S)-AHPC-C3-NH2 can be used in the synthesis of a series of PROTACs, such as UNC6852. UNC6852 is an EED-targeted bivalent chemical degrader.
DC46258 VHL Ligand-Linker Conjugates 17 VHL Ligand-Linker Conjugates 17 incorporates a VHL ligand for the E3 ubiquitin ligase, and a PROTAC linker. VHL Ligand-Linker Conjugates 17 can be used in the synthesis of a series of PROTACs, such as ARD-266. ARD-266 is a highly potent androgen receptor (AR) PROTAC degrader.
DC46256 N-Boc-SBP-0636457-O-C3-COOH N-Boc-SBP-0636457-OH is a synthesized E3 ligase ligand-linker conjugate that incorporates IAP ligand and a linker. N-Boc-SBP-0636457-OH can be used to design a PROTAC Bcl-xL degrader-1.
DC46255 Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker. Lenalidomide-propargyl-C2-amido-Ph-NH2 hydrochloride can be used to design the PROTAC MD-224.
DC46231 Pomalidomide-amido-C3-piperazine-N-Boc Pomalidomide-amido-C3-piperazine-N-Boc is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in the synthesis of PROTAC PD-1/PD-L1 degrader-1.
DC45712 Pomalidomide-amino-PEG3-NH2 hydrochloride Pomalidomide-amino-PEG3-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
DC45710 Pomalidomide-amino-PEG5-NH2 hydrochloride Pomalidomide-amino-PEG5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology.
DC45705 Thalidomide-NH-PEG1-NH2 hydrochloride Thalidomide-NH-PEG1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.
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