VU-0357121 (VU0357121)|modulator of mGlu5

Cas No.:	433967-28-3
Chemical Name:	4-butoxy-N-(2,4-difluorophenyl)benzamide
Synonyms:	VU 0357121
SMILES:	C(NC1=CC=C(F)C=C1F)(=O)C1=CC=C(OCCCC)C=C1
Formula:	C₁₇H₁₇F₂NO₂
M.Wt:	305.32
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

VU0357121 is a novel positive and highly selective allosteric modulator (PAM) of mGlu5R with EC50 of 33 nM.

In Vitro:

VU0357121 do not bind at the MPEP allosteric site of mGlu5, thus do not possess mGlu5 NAM activity. The A809V/rmGlu5 mutation inhibited the ability of VU0357121 to shift the glutamate concentration?response curve, whereas the response to VU0357121 is not altered by the F585I/rmGlu5 mutation. VU0357121 show weaker cooperativity in the Ca2+ mobilization assay in the low-expressing HEK293A-mGlu5 cell line.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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VU-0357121(VU0357121)