Y-320|cas 288250-47-5|DC Chemicals|Price|Buy

Cas No.:	288250-47-5
Chemical Name:	Y320; Y 320
Synonyms:	Y320; Y 320
SMILES:	N(C1=CC=C(Cl)C=C1)1C(C)=C(C(NC2=CC=C(N3CCC(N4CCOCC4)CC3)C(C#N)=C2)=O)C=N1
Formula:	C₂₇H₂₉ClN₆O₂
M.Wt:	505.01
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

Y-320 is a new phenylpyrazoleanilide immunomodulator; inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM.Y-320 inhibited IL-17 production by CD4 T cells stimulated with IL-15 with IC50 values of 20 to 60 nM. Oral administration of Y-320 (0.3 to 3 mg/kg) significantly inhibited the development and progression of arthritis and joint destruction with reduction of IL-17 mRNA expression in arthritic joints of type II collagen-induced arthritis (CIA) in DBA/1J mice. Y-320 in combination with anti-murine tumor necrosis factor-α monoclonal antibody showed a synergistic effect on mouse CIA. Moreover, therapeutic treatment with Y-320 (0.3 and 1 mg/kg orally) ameliorated CIA in cynomolgus monkeys [1].

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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