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AB-836

  Cat. No.:  DC72289  
Chemical Structure
2445597-31-7
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More than 5000 active chemicals with high quality for research!
Field of application
AB-836 is an orally active HBV capsid inhibitor. AB-836 inhibits viral replication by interacting with HBV core protein.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2445597-31-7
Chemical Name: AB-836
SMILES: FC1=C(C#N)C=C(NC(N(C)[C@H](C)C2=CNC(C3=C2C=C(F)C(F)=C3)=O)=O)C=C1
Formula: C20H15F3N4O2
M.Wt: 400.35
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_36740_DC72289_2445597-31-7
COA
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Cat. No. Product name Field of application
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DC72983 ZINC20451377 ZINC20451377 is a small molecule that binds to hepatitis B surface antigen (HBsAg) with high affinity (Kd=65.3 nM), reduces HBsAg levels and HBV virion secretion in cell culture model for HBV.
DC72290 DVR-01 DVR-01 is a HBV inhibitor with EC50 values of 1.7 and 1.6 μM in AML12HBV10 and HepDES19 cells, respectively. DVR-01 shows antiviral activity against drug-resistant HBV mutants with EC50s of 2.403-3.273 μM. DVR-01 can be used for the research of HBV infection and related diseases.
DC47259 Inarigivir ammonium Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug which can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) act as an RIG-I agonist to activate cellular innate immune responses.
DC47062 Bersacapavir Bersacapavir is a novel Hepatitis B Virus capsid assembly modulator.
DC11296 GLP-26 GLP-26 is a novel potent HBV capsid modulator that reduces secreted HBeAg in HepNTCPDL cells transfected with HBV wild type with EC50 of 0.7 uM.
DC76051 Rapavir Rapavir (JH-B10) is a selective and potent sodium taurocholate cotransporting polypeptide (NTCP) inhibitor with an IC50 value of 1.8 nM for the uptake of taurocholic acid-d4 (TCA-d4). Rapavir exerts antiviral activity by directly binding to NTCP and blocking the entry of the virus into cells during the HBV infection phase. Rapavir is promising for research of HBV infections.
DC76050 Morphothiadin mesylate Morphothiadin (GLS4) mesylate is a potent inhibitor of wild-type and Adefovir-resistant HBV replication with an IC50 value of 12 nM.
DC76049 KR019 KR019 is a potent HBV capsid assembly modulator, exhibits potent antiviral activity in HBV-replicating cells. KR019 binds to the hydrophobic pocket at the core protein dimer-dimer interface, misdirecting capsid assembly into genome-free capsids and thereby inhibiting viral replication.
DC76048 Destruxin B2 Destruxin B2 (compound 5) is a natural depsipeptide that can be inhibits hepatitis B surface antigen (HBsAg) secretion in Hep3B cells with an IC50 1.30 μM.
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