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AGN 192870

  Cat. No.:  DC49018  
Chemical Structure
166977-57-7
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More than 5000 active chemicals with high quality for research!
Field of application
AGN 192870 is a RAR neutral antagonist with Kds of 147, 33, and 42 nM for RARα, RARβ, and RARγ, respectively. AGN 192870 shows IC50s of 87 and 32 nM for RARαand RARγ, respectively. AGN 192870 shows RARβ partial agonism.
Cas No.: 166977-57-7
Chemical Name: AGN 192870
Formula: C27H24N4O
M.Wt: 378.46
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_32917_DC49018_166977-57-7
COA
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Cat. No. Product name Field of application
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DC77031 DC360 DC360 is a synthetic retinoid analogue of all-trans retinoic acid (ATRA) which induces RARβ expression. DC360 can be utilized in characterization of retinoid signalling pathways.
DC77030 BMS-185354 BMS-185354 is a selective RARγ activator with an EC50 value of 28 nM. BMS-185354 is promising for research of cancers.
DC73860 XS-060 XS-060 is a small molecule RXRα-targeted anti-mitotic agent, binds to RXRα (Kd=1.3 uM) and selectively inhibits the p-RXRα/PLK1 interaction to induce mitotic arrest and catastrophe in cancer cells.
DC73859 LG101506 LG101506 (LG1506) is a potent, selective and orally active RXR modulator with Ki of 2.6 nM.
DC73858 IRX4647 IRX4647 is a selective RARγ agonist, regulates T cell biology and reduces syngeneic tumor growth of immune checkpoint-resistant lung cancer cell line (344SQ) when combined with anti-PD-L1.
DC73857 E6060 E6060 is a potent, selective retinoic acid receptor subtype α (RAR-α) agonist with Ki of 0.2 nM, IC50 of 0.2 nM for RAR-α-mediated reporter transactivation assays.
DC73856 CD666 CD666 is a potent, selective RARgamma (RARγ) agonist.
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