alpha-Hederin|cas 27013-91-8|DC Chemicals

Cas No.:	27013-91-8
Chemical Name:	Sapindoside A
Synonyms:	ALPHA-HEDERIN;SAPINDOSIDE A;HEDERIN;HELIXIN;HEDERIN, ALPHA-;(3-beta,4-alpha)-nopyranosyl)oxy)-23-hydroxy;akebiasaponinpd;akebosidestc;alpha-hederine;glycosidel-e1;HEDERIN, ALPHA-(P) PrintBack;Olean-12-en-28-oicacid, 3-[[2-O-(6-deoxy-a-L-mannopyranosyl)-a-L-arabinopyranosyl]oxy]-23-hydr...;α-Hederin;A-HEDERIN;dipsacobioside;Hederoside B;hederosidec;koronaroside A;nepalin2;taurosidee;(3β,4α)-3-[[2-O-(6-Deoxy-α-L-mannopyranosyl)-α-L-arabinopyranosyl]oxy]-23-hydroxyolean-12-en-28-oic acid;[ "" ];CID 121241172;.alpha.-Hederin;NSC106553;STL454351;NCI60_000155;3-{[2-O-(6-Deoxyhexopyranosyl)pentopyr
SMILES:	O(C1([H])C([H])(C([H])(C([H])(C([H])([H])O1)O[H])O[H])OC1([H])C([H])(C([H])(C([H])(C([H])(C([H])([H])[H])O1)O[H])O[H])O[H])C1([H])C([H])([H])C([H])([H])C2(C([H])([H])[H])C([H])(C([H])([H])C([H])([H])C3(C([H])([H])[H])C4(C([H])([H])[H])C([H])([H])C([H])([H])C5(C(=O)O[H])C([H])([H])C([H])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])C5([H])C4=C([H])C([H])([H])C32[H])C1(C([H])([H])[H])C([H])([H])O[H]
Formula:	C₄₁H₆₆O₁₂
M.Wt:	750.9556
Purity:	>98%
Sotrage:	4°C for 1 year, -20°C for more than 2 years

Description:	Alpha-hederin is a water-soluble pentacyclic triterpenoid saponin, possessing several biological properties such as antispasmodic, moliscicidic, anthelmithic and inhibiting cell proliferation.
In Vivo:	Alpha-hederin had preventive effect on sensitized rats like thymoquinone. It may intervene in miRNA-126 expression, which consequently could interfere with IL-13 secretion pathway leading to a reduction in inflammatory responses.
In Vitro:	A-hederin is cytotoxic and inhibits proliferation in both cel lines at rather low concentrations. , a-hederin reduces the mitotic activity in treated cels.
References:	[1]. Danloy S et al. Effects of alpha-hederin, a saponin extracted from Hedera helix, on cells cultured in vitro. Planta Med, 1994 Feb, 60(1):45-9. [2]. Maryam Fallahi et al. Effect of Alpha-Hederin, the active constituent of Nigella sativa, on miRNA-126, IL-13 mRNA levels and inflammation of lungs in ovalbumin-sensitized male rats. Planta Med, 1994 Feb, 60(1):45-9.

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