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Bis-Pro-5FU (Compound 4) is a 5-FU precursor that confers oral bioavailability and increase the safety profile of 5-Fluorouracil (5-FU) chemotherapy regimens. 5-FU is an antineoplastic antimetabolite that is widely used for the research of colorectal and pancreatic cancer.
Fludarabine triphosphate (F-ara-ATP) trisodium, the active metabolite of Fludarabine, is a potent, noncompetitive and specific inhibitor of DNA primase, with an IC50 of 2.3 μM and a Ki of 6.1 μM. Fludarabine triphosphate trisodium inhibits DNA synthesis by blocking DNA primase and primer RNA formation. Fludarabine triphosphate trisodium inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis.
Fludarabine triphosphate (F-ara-ATP), the cytotoxic metabolite of Fludarabine phosphate, inhibits ribonucleotide reductase and DNA polymerase and ultimately leads to cellular apoptosis.
Ribavirin 5'-monophosphate dilithium is an active form of ribavirin that inhibits IMP dehydrogenase, and ribavirin itself is a broad-spectrum antiviral agent.
Pseudouridine 5'-OTBDPS (5-(5-O-TBDPS-β-D-ribofuranosyl)uracil) is an intermediate of Pseudouridine. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins.