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BRM/BRG1 ATP Inhibitor-1

  Cat. No.:  DC46193   Featured
Chemical Structure
2270879-17-7
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Field of application
BRM/BRG1 ATP Inhibitor-1 is an orally active inhibitors of Brahma Homolog (BRM)/SMARCA2 with IC50 below 0.005 µM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2270879-17-7
Chemical Name: BRM/BRG1 ATP Inhibitor-1
Synonyms: BRM/BRG1 ATP Inhibitor-1;1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea;TQR0285;Dual BRM and BRG1 inhibitor 14;BDBM50469330
SMILES: S1C(=CC(C(F)F)=N1)NC(NC1C=C(N=CC=1CO)F)=O
Formula: C11H9F3N4O2S
M.Wt: 318.274970769882
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: BRM/BRG1 ATP Inhibitor-1 is an allosteric dual brahma homolog (BRM)/SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 (SMARCA2) and brahma related gene 1 (BRG1)/SMARCA4 ATPase activity inhibitor, both IC50s are below 0.005 µM[1].
Target: IC50: ﹤0.005 µM (BRM, BRG1)[1]
References: [1]. Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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