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CG428

  Cat. No.:  DC70305   Featured
Chemical Structure
2412055-93-5
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More than 5000 active chemicals with high quality for research!
Field of application
CG428 (CG-428) is a first-in-class potent and selective TRK degrader (PROTAC) with DC50 of 0.36 nM.CG428 (CG-428) showed selectivity for the degradation of endogenous TPM3-TRKA over ectopically expressed ATP/GTP binding protein-like 4 (AGBL4)-TRKB or ETS variant transcription factor 6 (ETV6)-TRKC fusion proteins in KM12 cells.CG428 exhibited higher potency for inhibiting growth of KM12 cells with IC50 of 2.9 nM, compared with the parental TRK kinase inhibitor.CG428 (CG-428) is a valuable chemical tool compound for investigating the in vivo function of TRK fusion during tumorigenesis
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2412055-93-5
Chemical Name: CG428
Synonyms: CG 428;CG428;BDBM50554331;2412055-93-5;SCHEMBL21759979;AKOS040758533;CHEMBL4798635;PD155779;1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-[[2-[3-[4-[6-[6-[(2R)-2-(3-fluorophenyl)-1-pyrrolidinyl]imidazo[1,2-b]pyridazin-3-yl]-2-pyridinyl]-1-piperazinyl]-3-oxopropoxy]ethyl]amino]-
SMILES: FC1=CC=CC(=C1)[C@H]1CCCN1C1C=CC2=NC=C(C3=CC=CC(=N3)N3CCN(C(CCOCCNC4=CC=CC5C(N(C(C=54)=O)C4C(NC(CC4)=O)=O)=O)=O)CC3)N2N=1
Formula: C43H43FN10O6
M.Wt: 814.863332033157
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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