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COH34

  Cat. No.:  DC42744   Featured
Chemical Structure
906439-72-3
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More than 5000 active chemicals with high quality for research!
Field of application
Novel potent and cell-active PARG inhibitor, selectively killing BRCA-mutant and PARP inhibitor-resistant cancer cells
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 906439-72-3
Chemical Name: (E)-1-(((p-Tolylthio)imino)methyl)naphthalen-2-ol
Synonyms: COH34; COH-34; COH 34
SMILES: OC1=CC=C2C=CC=CC2=C1/C=N/SC3=CC=C(C)C=C3
Formula: C18H15NOs
M.Wt: 293.38
Purity: >98%
Sotrage: 0°C (short term), -20°C (long term), desiccated
Description: COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC50 of 0.37 nM. COH34 binds to the catalytic domain of PARG (Kd=0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors[1].
Target: IC50: 0.37 nM (PARG)[1]
In Vivo: COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models[1].
In Vitro: COH34 efficiently kills PARP inhibitor-resistant cancer cells[1].
References: [1]. Chen SH, et al. Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies. Sci Adv. 2019 Apr 10;5(4):eaav4340.
MSDS
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MSDS_26373_DC42744_906439-72-3
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