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CQ627

Cat. No.: DC67380 Featured

Chemical Structure

For research use only. We do not sell to patients.

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Field of application

CQ627 is a targeted molecular glue that promotes RIOK2 degradation through the ubiquitin-proteasome pathway by bridging interactions between RIOK2 and the E3 ligase RNF126, achieving a DC50 of 410 nM in MOLT4 leukemia cells. This compound demonstrates multi-modal anticancer activity, including: (1) dose-dependent apoptosis induction, (2) G2/M phase cell cycle arrest, and (3) broad-spectrum antiproliferative effects across cancer cell lines. Furthermore, CQ627 shows significant in vivo efficacy in MOLT4 xenograft models, validating its therapeutic potential.

Chemicals Properties Biological activity Related products COA MSDS Datasheet

Cas No.:
Chemical Name:	CQ627
SMILES:	FC1=CC=C(C(/C=C/C(N2CCN(C3=C(C(F)(F)F)C=C(N4N=NC5=C4C6=CC(C7=CC=C(OC)N=C7)=CC=C6NC5=O)C=C3)CC2)=O)=O)C=C1
Formula:	C₃₆H₂₇F₄N₇O₄
M.Wt:	697.64
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC68076	BG-BRD4-P07
DC68075	BRU-SHP2-P06
DC68074	LLY-ESR1-P05
DC68073	AST-AR-P04
DC68072	NOV-EP001
DC68071	JHU-MDM2-P03
DC68070	CAS-FAK-P02
DC68069	MDA-S24-P01
DC68068	TB-008
DC68067	ARV-863

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.