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CRT5

  Cat. No.:  DC42667   Featured
Chemical Structure
1034297-58-9
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More than 5000 active chemicals with high quality for research!
Field of application
CRT5 is a pyrazine benzamide that prevents activation of all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1034297-58-9
Chemical Name: 3-[6-amino-5-(6-ethoxy-2-naphthalenyl)-3-pyridinyl]-N-[2-(dimethylamino)ethyl]-benzamide
Synonyms: CRT0066051; CRT 5; CRT-5 CRT 0066051;CRT-0066051;
SMILES: CCOC1=CC=C2C(C=CC(C3=CC(C4=CC(C(NCCN(C)C)=O)=CC=C4)=CN=C3N)=C2)=C1
Formula: C20H30N4O2
M.Wt: 454.56
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Publication: 1. Evans, I.M., Bagherzadeh, A., Charles, M., et al. Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells. Biochemistry Journal 429(3), 565-572 (2010).
Description: CRT5, a pyrazine benzamide, is a potent and selective inhibitor for all three isoforms of PKD in endothelial cells treated with VEGF (IC50s = 1, 2, and 1.5 nM for PKD1, PKD2, and PKD3, respectively). CRT5 decreases VEGF-induced endothelial migration, proliferation and tubulogenesis[1].
References: [1]. Evans IM, et al. Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells. Biochem J. 2010 Aug 1;429(3):565-72.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
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