DS42450411|CAS|DC Chemicals

Cas No.:
Chemical Name:	8-{1-[(1R,4R)-4-aminocyclohexyl]ethenyl}-5,5-dimethyl-5,6-dihydrobenzo[h]quinazolin-4-amine
Synonyms:	DS42450411\|DS 42450411;DS-42450411
SMILES:	NC1=C2C(C)(C)CC3=CC(C([C@H]4CC[C@H](N)CC4)=C)=CC=C3C2=NC=N1
Formula:	C₂₂H₂₈N₄
M.Wt:	348.494
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

DS42450411 (DS 42450411, DS-42450411) is a potent, orally active hepcidin production inhibitor with IC50 of 32 nM; The inhibition of hepcidin production of DS42450411 was suggested to be through the inhibition of DYRK1a or a kinase belonging to CMGC family; shows serum hepcidin-lowering effects in a mouse model of interleukin-6-induced acute inflammation.

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8-{1-[(1R,4R)-4-aminocyclohexyl]ethenyl}-5,5-dimethyl-5,6-dihydrobenzo[h]quinazolin-4-amine