6R-FR054|CAS 10378-06-0|DC Chemicals

Cas No.:	10378-06-0
Chemical Name:	5H-Pyrano[3,2-d]oxazole-5-methanol,6,7-bis(acetyloxy)-3a,6,7,7a-tetrahydro-2-methyl-, acetate (ester)
SMILES:	CC(=O)OCC1C(OC(C)=O)C(OC(C)=O)[C@@H]2[C@@H](OC(C)=N2)O1
Formula:	C₁₄H₁₉NO₈
M.Wt:	329.30256
Purity:	>98%
Sotrage:	0°C (short term), -20°C (long term), desiccated

Description:	(6R)-FR054 is an active isomer of FR054. FR054 is an inhibitor of the HBP enzyme PGM3, with a remarkable anti-breast cancer effect. FR054induces endoplasmic reticulum (ER) stress and a ROS-dependent apoptosis[1].
References:	[1]. Francesca Ricciardiello, et al. Inhibition of the Hexosamine Biosynthetic Pathway by Targeting PGM3 Causes Breast Cancer Growth Arrest and Apoptosis. Cell Death Dis. 2018 Mar 7;9(3):377.

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