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GSK'843

  Cat. No.:  DC43088   Featured
Chemical Structure
1601496-05-2
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More than 5000 active chemicals with high quality for research!
Field of application
Selective RIP3 kinase inhibitor
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1601496-05-2
Chemical Name: GSK-843
Synonyms: GSK843;AOB4898;GSK'843;3-(benzo[d]thiazol-5-yl)-7-(1,3-dimethyl-1H-pyrazol-5-yl)thieno[3,2-c]pyridin-4-amine;3-(1,3-Benzothiazol-5-yl)-7-(2,5-dimethylpyrazol-3-yl)thieno[3,2-c]pyridin-4-amine;GSK-843
SMILES: S1C=C(C2C=CC3=C(C=2)N=CS3)C2C(N)=NC=C(C3=CC(C)=NN3C)C1=2
Formula: C19H15N5S2
M.Wt: 377.485900163651
Purity: >98%
Sotrage: 0°C (short term), -20°C (long term), desiccated
Description: GSK-843 is a receptor-interacting protein kinase 3 (RIP3 or RIPK3) inhibitor, which binds RIP3 kinase domain with an IC50 of 8.6 nM, and inhibits kinase activity with an IC50 of 6.5 nM[1].
Target: IC50: 6.5 nM (RIP3)[1]
References: [1]. Mandal P, et al. RIP3 induces apoptosis independent of pronecrotic kinase activity. Mol Cell. 2014 Nov 20;56(4):481-95.
MSDS
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MSDS_26714_DC43088_1601496-05-2
COA
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