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HGC652

  Cat. No.:  DC67394   Featured
Chemical Structure
3055558-98-7
For research use only. We do not sell to patients.
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More than 5000 active chemicals with high quality for research!
Field of application
HGC652 is a first-in-class molecular glue that selectively recruits the E3 ubiquitin ligase TRIM21 to form a ternary complex with NUP98, triggering targeted degradation of NUP155 and nuclear pore complex (NPC) proteins. This unique mechanism induces potent cytotoxicity across multiple cancer types, with activity correlating with cellular TRIM21 expression levels.
Cas No.: 3055558-98-7
Chemical Name: HGC652
SMILES: CN(C(C1=CC=C(C2=C(SC)C=C(F)C=C2)C=C1S(=O)(C)=O)=O)CC3CCCCC3
Formula: C23H28FNO3S2
M.Wt: 449.60
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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