GDC0214 |GDC-0214|CAS JAK inhibitor|DC Chemicals

Cas No.:	1831144-46-7
Chemical Name:	N-(3-(5-chloro-2-(difluoromethoxy)phenyl)-1-(2-(4-((2-cyanoethyl)(methyl)amino)piperidin-1-yl)-2-oxoethyl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide
Synonyms:	iJak381
SMILES:	C12=C(C(NC3=CN(CC(N4CCC(N(CCC#N)C)CC4)=O)N=C3C3=CC(Cl)=CC=C3OC(F)F)=O)C=NN1C=CC=N2
Formula:	C₂₈H₂₈ClF₂N₉O₃
M.Wt:	612.039
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Description:

iJak-381 (iJak381) is a potent, selective inhalable and lung-restricted inhibitor of JAK1 with IC50 of 8.52 nM, displays 6.3/704/28 fold selectivity over JAK2/JAK3/TYK2; suppresses STAT 6 activation by IL-1, suppresses ovalbumin-induced lung inflammation in both murine and guinea pig asthma models and improved allergen-induced airway hyperresponsiveness in mice; In a model driven by human allergens, iJak-381 had a more potent suppressive effect on neutrophil-driven inflammation compared to systemic corticosteroid administration, reduces lung pathology without affecting systemic Jak1 activity in rodents.

MSDS

COA

LOT NO.	DOWNLOAD

2018-0101
2018-0101

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GDC-0214(GDC0214)