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JP-2-249

  Cat. No.:  DC67377   Featured
Chemical Structure
3036530-41-0
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More than 5000 active chemicals with high quality for research!
Field of application
JP-2-249 functions as a molecular glue degrader that selectively targets SMARCA2 for proteasomal degradation. In MV-4-11 leukemia cells, treatment with JP-2-249 (1–10 μM) induces dose-dependent reduction of SMARCA2 protein levels, demonstrating potent degradation activity.
Cas No.: 3036530-41-0
Chemical Name: JP-2-249
SMILES: COC1=CC=C(C(/C=C/C(N2CCN(C3=C(N)N=NC(C4=CC=CC=C4O)=C3)CC2)=O)=O)C=C1
Formula: C25H25N5O4
M.Wt: 459.50
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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