K-8794|CAS 180577-26-8|DC Chemicals

Cas No.:	180577-26-8
Chemical Name:	K-8794
SMILES:	O=C(CCOC1=NC(C2=NC=CC=N2)=NC(NS(=O)(C3=CC=C(C(C)(C)C)C=C3)=O)=C1OC4=C(OC)C=CC=C4)NC5=C(C)C=CC=C5C
Formula:	C₃₆H₃₈N₆O₆S
M.Wt:	682.79
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

MSDS

Cat. No.	Product name	Field of application
DC41590	Sarafotoxin S6a TFA	Sarafotoxin S6a TFA , a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3. Sarafotoxin S6a TFA elicits the pig coronary artery with an EC50 value of 7.5 nM.
DC41589	Sarafotoxin S6a	Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ETA/ETB selectivity profile similar to that of Endothelin-3. Sarafotoxin S6a elicits the pig coronary artery with an EC50 value of 7.5 nM.
DC40074	Nebentan potassium	Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan. Nebentan potassium inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo.
DC40073	Nebentan	Nebentan (YM598 free base) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan. Nebentan inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo.
DC11513	Aprocitentan (ACT-132577)	Aprocitentan (ACT-132577) is the major and pharmacologically active metabolite of macitentan, which is dual ETA/ETB antagonist designed for tissue targeting.
DC8191	Sparsentan(PS433540)	Sparsentan (RE-021) is a highly potent dual angiotensin II and endothelin A receptor antagonist with Kis of 0.8 and 9.3 nM, respectively[1].
DC76526	Sulfatroxazole	Sulfatroxazole (Isosulfafurazole) (compound 12) is a selective antagonist of ETA receptor (IC50=0.26 μM).
DC76525	K-8794	K-8794 is an orally active selective endothelin receptor ETB antagonist that can be used in research on cardiovascular diseases.
DC72191	Clazosentan	Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction.
DC71774	Vodudeutentan	Vodudeutentan is an endothelin receptor antagonist.