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L-760735

  Cat. No.:  DC71346  
Chemical Structure
188923-01-5
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More than 5000 active chemicals with high quality for research!
Field of application
L-760735 is a high affinity, selective and orally active NK1 receptor antagonist with an IC50 of 0.19 nM for human NK1 receptors. L-760735 exhibits anxiolytic and antidepressant-like effects.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 188923-01-5
SMILES: C[C@H](C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)O[C@@H](OCC2)[C@@](C3=CC=C(C=C3)F)([H])N2CC4=C(N=NN4)CN(C)C.Cl
M.Wt: 611.98
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC46850 SB 218795 SB 218795 is a potent and selective non-peptide NK3 receptor antagonist, with a Ki 13 nM for hNK3. SB 218795 shows about 90-fold and 7000-fold selectivity for hNK3 over hNK2 and hNK1, respectively. SB 218795 can inhibit NK3 receptor-mediated pupillary constriction of the rabbit.
DC28971 Osanetant Osanetant (SR142801) is a selective NK3 receptor antagonist. Osanetant produces anxiolytic- and antidepressant-like effects and is researched for schizophrenia.
DC28435 Orvepitant maleate Orvepitant maleate (GW823296 maleate) is potent, selective, orally active and well-tolerated neurokinin-1 receptor (NK-1) antagonist with a pKi of 10.2 for human neurokinin-1 receptor. Orvepitant maleate can across the blood-brain barrier. Orvepitant maleate has the potential for depressive disorder and chronic refractory cough (CRC) treatment.
DC7245 SB 222200 SB 222200 is a selective, reversible and competitive antagonist of human NK-3 receptor(Ki=4.4 nM) that effectively crosses the blood-brain barrier.
DC11755 L-732138 A potent, selective and competitive NK1 receptor antagonist with IC50 of 2.3 nM.
DC76582 WIN 62577 WIN 62577 is a species-selective tachykinin NK1 receptor antagonist. WIN 62577 is also an allosteric enhancer with micromolar potency at M3 receptors. WIN 62577 exhibits potent antiviral activity against SARS-CoV-2.
DC76581 Osanetant monohydrochloride Osanetant (SR142801) monohydrochloride is a selective NK3 receptor antagonist. Osanetant monohydrochloride produces anxiolytic- and antidepressant-like effects.
DC76580 CP 122721 CP 122721 is an orally active NK1 receptor antagonist. CP 122721 attenuates cisplatin-induced vomiting in ferrets (ID50: 0.08 mg/kg). CP 122721 inhibits kainate (KA)-induced seizure activity and CA1 neuronal cell death in rats. CP 122721 is useful in the study of depression, asthma, and irritable bowel syndrome (IBS).
DC76579 ASN-1377642 ASN-1377642 is a NK1 receptor antagonist with a Ki value of 251 nM. ASN-1377642 shows antitumor action in breast cancer cells with NK1R-Tr high expression.
DC76578 Anthrotainin Anthrotainin, a tetracyclic compound, is a substance P binding inhibitor with an IC50 of 3 μM.
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