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LL-K12-18

Cat. No.: DC60634 Featured

Chemical Structure

For research use only. We do not sell to patients.

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Field of application

LL-K12-18 is a highly potent dual-site molecular glue that induces the formation of the CDK12-DDB1 complex, exhibiting an EC50 of 0.37 nM. It demonstrates 80-fold greater potency than SR-4835 in MDA-MB-231 cells and a remarkable 307-fold increase in potency (EC50 = 0.03 nM) in MDA-MB-468 cells, while its degradation efficiency (DC50 = 0.38 nM) is 50-fold enhanced.

Chemicals Properties Biological activity Related products COA MSDS Datasheet

Cas No.:
Chemical Name:	LL-K12-18
SMILES:	CCN1C=NC2=C1N=C(N(CC3)CCN3C(CN(CC)CC)=O)N=C2NCC4=NC5=CC(Cl)=C(C=C5N4)Cl
Formula:	C₂₅H₃₂Cl₂N₁₀O
M.Wt:	559.49
Purity:	98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC68076	BG-BRD4-P07
DC68075	BRU-SHP2-P06
DC68074	LLY-ESR1-P05
DC68073	AST-AR-P04
DC68072	NOV-EP001
DC68071	JHU-MDM2-P03
DC68070	CAS-FAK-P02
DC68069	MDA-S24-P01
DC68068	TB-008
DC68067	ARV-863

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.