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Mg-277

Cat. No.: DCC3332 Featured

Chemical Structure

2411085-89-5

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Field of application

MG-277, a molecular glue degrader, efficiently induces the degradation of the translation termination factor GSPT1, based on the Cereblon E3 ligand, with a DC50 of 1.3 nM. It potently inhibits tumor cell growth in a p53-independent manner, demonstrating IC50 values of 3.5 nM for RS4;11 cells and 3.4 nM for p53 mutant RS4;11/IRMI-2 cells. MG-277 exhibits significant anticancer activity.

Chemicals Properties Biological activity Related products COA MSDS Datasheet

Cas No.:	2411085-89-5
Chemical Name:	MG-277
Synonyms:	MG-277;GTPL11724;MG277;BDBM50505628;CID 139600332;2411085-89-5;G17138;T12027;CHEMBL4449512;CS-0105162;HY-130122;MS-31404;AKOS040733728
SMILES:	ClC1C=CC2=C(C=1)NC([C@@]12[C@@H](C2C=CC=C(C=2F)Cl)[C@H](C(NCCCCCC2=CC=CC3C(N(C4C(NC(CC4)=O)=O)CC2=3)=O)=O)NC21CCCCC2)=O
Formula:	C₄₁H₄₂Cl₂FN₅O₅
M.Wt:	774.7
Purity:	>98%
Sotrage:	2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO

Cat. No.	Product name	Field of application
DC68076	BG-BRD4-P07
DC68075	BRU-SHP2-P06
DC68074	LLY-ESR1-P05
DC68073	AST-AR-P04
DC68072	NOV-EP001
DC68071	JHU-MDM2-P03
DC68070	CAS-FAK-P02
DC68069	MDA-S24-P01
DC68068	TB-008
DC68067	ARV-863

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.