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OPB-171775

  Cat. No.:  DC60624   Featured
Chemical Structure
2131210-15-4
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More than 5000 active chemicals with high quality for research!
Field of application
OPB-171775 represents a breakthrough in GIST treatment as a first-in-class, non-tyrosine kinase inhibitor (non-TKI) compound that demonstrates potent antitumor activity independent of KIT mutation status. Unlike conventional TKIs that target oncogenic kinases, OPB-171775 operates through an innovative mechanism by orchestrating a protein-protein interaction between phosphodiesterase 3A (PDE3A) and Schlafen 12 (SLFN12).
Chemicals PropertiesBiological activity Related products COA MSDS Datasheet
Cas No.: 2131210-15-4
Chemical Name: OPB-171775
Synonyms: (4R)-3-[2,3-difluoro-4-(2-hydroxy-2-methylpropoxy)phenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one;(4R)-3-[2,3-difluoro-4-(2-hydroxy-2-methylpropoxy)phenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one;GTPL13643;GTPL13643;GTPL13643;OPB-171775;OPB-171775;OPB-171775;EX-A9729;EX-A9729;EX-A9729;EX-A9729;OPB171775;OPB171775;OPB171775;OPB171775;Example 124 [US20190023662];Example 124 [US20190023662];Example 124 [US20190023662];Example 124 [US20190023662];SCHEMBL20607360;SCHEMBL20607360;SCHEMBL20607360;SCHEMBL20607360;HY-162730;HY-162730;HY-162730;2131210-15-4;2131210-15-4;HY-162730;2131210-15-4;2131210-15-4
SMILES: FC1C(=C(C=CC=1C1[C@H](C)CC(NN=1)=O)OCC(C)(C)O)F
Formula: C15H18F2N2O3
M.Wt: 312.31
Purity: 98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
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