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P11149

  Cat. No.:  DC44534  
Chemical Structure
164724-79-2
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More than 5000 active chemicals with high quality for research!
Field of application
P11149 is a competitive, BBB-penetarated weakly, orally active and selective inhibitor of AChE. P11149 exhibits an IC50 of 1.3 μM for rat BChE/AChE. P11149, a Galanthamine derivative, demonstrates central cholinergic activity, behavioral efficacy and safety. P11149 is used in the study for Alzheimer's disease.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 164724-79-2
Chemical Name: P11149
SMILES: O=C(C12C[C@H](C3)C[C@H](C[C@H]3C2)C1)OC4=CC=C5C6=C4O[C@]7([H])[C@@]6(CCN(C)C5)C=C[C@H](O)C7.[H]Cl
Formula: C27H34ClNO4
M.Wt: 472.02
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_28216_DC44534_164724-79-2
COA
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Cat. No. Product name Field of application
DC47776 Millmerranone A Millmerranone A shows the acetylcholinesterase inhibitory property.
DC47775 Chikusetsusaponin Ib Chikusetsusaponin Ib has anti-Alzheimer's disease activity and is a potent AChE inhibitor.
DC47774 Cyclopenin Cyclopenin ((±)-Isocyclopenine) is a racemate.
DC47773 Cyclanoline chloride Cyclanoline (chloride) shows cholinesterase inhibitory activity.
DC47772 Isonaringin Isonaringin shows anti-Alzheimer’s activity by inhibiting AChE.
DC47239 Zanapezil free base Zanapezil (TAK-147) free base is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor. Zanapezil free base shows a potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). Zanapezil free base shows a moderate inhibition of muscarinic M1 and M2 receptor binding with Ki values of 234 and 340 nM, respectively. Zanapezil free base can be used for the research of early stages of Alzheimer's disease (AD).
DC46568 Acotiamide D6 Acotiamide D6 is a deuterium labeled Acotiamide. Acotiamide is an orally active and first-in-class gastroprokinetic agent for the treatment of functional dyspepsia.
DC46069 Echimidine N-oxide Echimidine N-oxide, a pyrrolizidine alkaloid, has acetylcholinesterase (AChE) inhibitory activity (IC50=0.347 mM).
DC45995 Manghaslin Manghaslin is a flavonoid glycoside with anti-inflammatory activities. Manghaslin shows inhibitory activity against AChE with an IC50 of 94.92 µM.
DC44782 O-Desmethyl Galanthamine O-Desmethyl Galanthamine (Sanguinine) is galanthamine-type alkaloid. O-Desmethyl Galanthamine is an acetylcholinesterase (AChE) inhibitor, with an IC50 1.83 μM.
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