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SB-328437

  Cat. No.:  DC48823   Featured
Chemical Structure
247580-43-4
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More than 5000 active chemicals with high quality for research!
Field of application
SB-328437 is a potent, selective non-peptide CCR3 antagonist with an IC50 of 4.5 nM.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 247580-43-4
Chemical Name: methyl (2S)-2-(naphthalene-1-carbonylamino)-3-(4-nitrophenyl)propanoate
Synonyms: (S)-METHYL-2-NAPHTHOYLAMINO-3-(4-NITROPHENYL)PROPIONATE;methyl (2S)-2-(naphthalene-1-carbonylamino)-3-(4-nitrophenyl)propanoate;SB 328437;N-(1-Naphthalenylcarbonyl)-4-nitro-L-phenylalanineMethylester;L-Phenylalanine, N-(1-naphthalenylcarbonyl)-4-nitro-, methyl ester;HMS3414E05;HMS3678E05;BDBM50100021;N-(1-NAPHTHALENYLCARBONYL)-4-NITRO-L-PHENYLALANINE METHYL ESTER;SB 328437, >=98% (HPLC);(S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-ni
SMILES: O(C)C([C@H](CC1C=CC(=CC=1)[N+](=O)[O-])N([H])C(C1=CC=CC2=CC=CC=C12)=O)=O
Formula: C21H18N2O5
M.Wt: 378.378025531769
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
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DC73393 alpha-NETA alpha-NETA (α-NETA) is a small molecule antagonist of chemerin receptor chemokine-like receptor 1 (CMKLR1), inhibits chemerin-stimulated β-arrestin2 association with CMKLR1 with IC50 of 4.9 uM.
DC72882 MR120 MR120 (CCR6 antagonist 1b) is a potent, selective CCR6 antagonist, disrupts the CCL20-induced chemotaxis of CCR6+CD4+ T cells.
DC72766 PF-07054894 PF-07054894 is a potent CCR6 antagonist. PF-07054894 targets G protein-coupled receptor (GPCR). PF-07054894 can be used in research of inflammatory bowel disease.
DC72524 FLX475 FLX475 is a potent CCR4 antagonist that blocks regulatory T cells that interfere with effective antitumor immune responses and has antitumor activity.
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DC70817 SX-682 SX-682 (SX682) is a potent, allosteric, orally bioavailable inhibitor of CXCR1 and CXCR2.SX-682 enhances tumor infiltration, activation, and the therapeutic efficacy of adoptively transferred NK cells.SX-682 significantly inhibits trafficking of PMN-MDSCs without altering CXCR2 ligand expression.SX-682 enhances T cell-based immunotherapeutic efficacy.
DC70602 ML339 ML 339 is a potent and selective hCXCR6 antagonist (IC50 = 140 nM), 100-fold less active at the murine CXCR6 receptor (IC50 = 18 uM); ML 339 exhibits selectivity over CXCR5, CXCR4, CCR6 and APJ receptors.
DC70333 CXCR6 inhibitor 81 CXCR6 inhibitor 81 is a potent (EC50=40 nM) and selective orally bioavailable small molecule antagonist of human CXCR6 receptor; Compound 81 displays >10-fold improvement in potency in both the β-arrestin and cAMP assays (IC50 =40 and 540 nM, respectively) compared to ML339. CXCR6 inhibitor 81 inhibits migration of SK-HEP-1 hepatoma cells in a dose dependent manner. Compound 81 has promising oral DMPK data, significantly decreases tumor growth in a 30-day mouse xenograft model of HCC.
DC70292 CCR4-IN-38 CCR4-IN-38 (CCR4-351) is a potent, selective, orally bioavailable CCR4 antagonist with IC50 of 50 nM (Chemotaxis inhibition).CCR4-IN-38 inhibits the recruitment of Treg into the tumor microenvironment (TME).CCR4-IN-38 elicits antitumor responses as a single agent or in combination with an immune checkpoint blockade.
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