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Home > Molecular Glues

SJPYT-195

  Cat. No.:  DC71971   Featured
Chemical Structure
2973762-16-0
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More than 5000 active chemicals with high quality for research!
Field of application
SJPYT-195 is a potent cytotoxic degrader of GSPT1, serving as a valuable compound for PROTAC (proteolysis-targeting chimera) synthesis and targeted protein degradation research.
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2973762-16-0
Chemical Name: Sjpyt-195
Synonyms: SJPYT195;CHEMBL5172753;GLXC-25989;SCHEMBL26732477;N-(3-(tert-Butyl)-5-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)phenyl)-1-(2,5-dimethoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxamide;CS-0534878;SJPYT-195;G76732
SMILES: O(C1=CC(=CC(=C1)C(C)(C)C)NC(C1=C(C)N(C2C=C(C=CC=2OC)OC)N=N1)=O)C1=CC=CC2C(N(C(C=21)=O)C1C(NC(CC1)=O)=O)=O
Formula: C35H34N6O8
M.Wt: 666.679868221283
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
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DC60858 LC-04-045 LC-04-045 is a leading NEK7 molecular glue degrader with DC50 of 7 nM and Dmax of 90 % in MOLT-4 cells. LC-04-045 displays high selectivity for NEK7 across the proteome.
DC60852 PVTX-405 PVTX-405 is a potent, effective, highly selective, and orally efficacious IKZF2 molecular glue degrader with DC50 of  0.7 nM. PVTX-405 in combination with anti-PD1 or anti-LAG3 significantly increases animal survival compared to anti-PD1 or anti-LAG3 alone.
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DC67413 MRT-23227
DC67412 MRT-3486 MRT-3486 (Compound 5) is a cereblon-based NEK7 molecular glue degrader. MRT-3486 can be used for autoinflammatory diseases research.
DC67411 MRT-7612
DC67410 MRT-10350
DC67407 IKZF1-degrader-1 IKZF1-degrader-1 (Compound 9-B) is a highly potent molecular glue that achieves sub-nanomolar degradation of IKZF1 (DC50 = 0.134 nM), demonstrating significant therapeutic potential for targeting IKZF1-dependent malignancies.
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