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SMS2-IN-1

  Cat. No.:  DC43994   Featured
Chemical Structure
2098890-15-2
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Field of application
SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC50 of 1000 nM).
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 2098890-15-2
Chemical Name: SMS2-IN-1
Synonyms: 1-​Piperidinecarboxylic acid, 4-​[3-​[[3-​[[[[3,​5-​bis(trifluoromethyl)​phenyl]​methyl]​methylamino]​carbonyl]​-​1,​2-​dihydro-​1-​methyl-​2-​oxo-​4-​quinolinyl]​oxy]​propyl]​-​, 1-​methylcyclopropyl ester;SMS2-IN-1
SMILES: C1(C)(CC1)OC(N1CCC(CCCOC2=C(C(N(CC3C=C(C(F)(F)F)C=C(C(F)(F)F)C=3)C)=O)C(=O)N(C)C3C2=CC=CC=3)CC1)=O
Formula: C34H37F6N3O5
M.Wt: 681.67
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: SMS2-IN-1 is a highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM.
Target: IC50: 6.5 nM (SMS2)[1]
References: [1]. Adachi R, et al. Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors. Eur J Med Chem. 2017 Aug 18;136:283-293.
MSDS
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MSDS_27662_DC43994_2098890-15-2
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