ssPalmO-Phe|Ionizable Lipid for LNP

Cas No.:	2377474-67-2
Chemical Name:	ssPalmO-Phe
Synonyms:	Benzeneacetic acid, 4-[[(9Z )-1-oxo-9-octadecen-1-yl]oxy]-, 1,1′-[dithiobis(2,1-ethanediyl-1,4-piperidinediyl-2,1-ethanediyl)] ester (ACI);ssPalmOPhe， ssPalmO Phe
SMILES:	C(C(OCCC1CCN(CCSSCCN2CCC(CCOC(CC3=CC=C(OC(CCCCCCC/C=C\CCCCCCCC)=O)C=C3)=O)CC2)CC1)=O)C4=CC=C(OC(CCCCCCC/C= C\CCCCCCCC)=O)C=C4
Formula:	C₇₀H₁₁₂N₂O₈S₂
M.Wt:	1173.777
Purity:	ELSD-HPLC>95%
Sotrage:	1 year -20°C
Publication:	H. Tanaka, A. Watanabe, M. Konishi, Y. Nakai, H. Yoshioka, T. Ohkawara, H. Takeda, H. Harashima, H. Akita, Heliyon 2018, 4, e00959.

Cat. No.	Product name	Field of application
DC59002	ssPalmO-Phe	ssPalmO-Phe(SS-OP) is a self-degradable material for the delivery of oligonucleotides. ssPalmO-Phe is a self-degradable derivative of ssPalm that is self-degraded in the intraparticle space by a specific hydrolytic reaction. ssPalmO-Phe is beneficial for overcoming the plasma/endosomal membrane, LNP-ssPalmO-Phe can be used to deliver both nucleic acids.
DC57006	L319	L319 (LIPID 319) is a novel ionizable, biodegradable lipid for delivery of short interfering RNAs (siRNAs). L319-LPN displays rapid elimination with pKa of 6.38 and also shows well tolerated up to 10 mg/kg.