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NS8593

  Cat. No.:  DC81175  
Chemical Structure
819861-41-1
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More than 5000 active chemicals with high quality for research!
Field of application
NS8593 is an SK channel (small conductance Ca2+-activated K+ channels) inhibitor. NS8593 reversibly inhibited recombinant SK3-mediated currents (human SK3 and rat SK3). NS8593 inhibits all the SK1-3 subtypes Ca2+-dependently (Kd = 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca2+). NS8593 does not affect the Ca2+-activated K channels of intermediate and large conductance (hlk and hBK channels, respectively). NS8593 can also inhibit TRPM7 (melastatin-related TRP cation channel 7) (IC50 = 1.6 mM). NS8593 can be used for the study of central nervous system (CNS) related diseases.
Cas No.: 819861-41-1
Chemical Name: NS8593
Formula: C20H17NO5
M.Wt: 351.35
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Cat. No. Product name Field of application
DC81110 N6-Hydroxynorvalylcarbamoyladenosine N6-Hydroxynorvalylcarbamoyladenosine (hn6A) (compound 1) is a nucleoside discovered in unfractionated tRNA from Thermodesulfobacterium commune. N6-Hydroxynorvalylcarbamoyladenosine is a modified nucleoside.
DC80069 3'-O-(2-Nitrobenzyl)-dTTP 3'-O-(2-Nitrobenzyl)-dTTP acts as a reversible terminator for DNA chain elongation. 3'-O-(2-Nitrobenzyl)-dTTP interacts with 9°N polymerase (exo-) A485L/Y409V, gets recognized and incorporated into the elongating DNA chain, thereby temporarily terminating the polymerase reaction. 3'-O-(2-Nitrobenzyl)-dTTP carries a 3'-O-(2-nitrobenzyl) blocking group, which can be removed by laser irradiation to regenerate the free 3'-OH− group and restore polymerase activity. 3'-O-(2-Nitrobenzyl)-dTTP is applicable in DNA sequencing studies.
DC80066 3'-O-(2-Nitrobenzyl)-dATP 3'-O-(2-Nitrobenzyl)-dATP is a reversible and photolabile DNA synthesis terminator. 3'-O-(2-Nitrobenzyl)-dATP incorporates into growing DNA strands to terminate synthesis in a base-specific manner. 3'-O-(2-Nitrobenzyl)-dATP undergoes efficient photolytic removal of its 3'-protecting group upon UV exposure to enable reinitiation of DNA synthesis. 3'-O-(2-Nitrobenzyl)-dATP supports development of the Base Addition Sequencing Scheme (BASS) via a complete stop-start DNA synthesis cycle.
DC80060 3-Chloropropan-1-amine hydrochloride 3-Chloropropan-1-amine hydrochloride is a PROTAC linker that can be used in the synthesis of PROTACs.
DC80050 3-(4-Bromophenyl)propanoic acid 3-(4-Bromophenyl)propanoic acid is a PROTAC linker that can be used in the synthesis of PROTACs.
DC80036 2-Bromo-LSD D-Tartrate 2-Bromo-LSD D-Tartrate is a blood-brain barrier-permeable 5-HT2A partial agonist and competitive partial antagonist. 2-Bromo-LSD D-Tartrate acts as both a potent partial agonist (with an EC50 of 0.81 nM for Gq dissociation) and a potent partial antagonist (with a KB of 0.18 nM for Gq dissociation) at the 5-HT2A receptor. 2-Bromo-LSD D-Tartrate exhibits partial agonist activity at multiple aminergic GPCRs, including 5-HT2A. 2-Bromo-LSD D-Tartrate lacks 5-HT2B agonist activity. 2-Bromo-LSD D-Tartrate induces dendritogenesis and spinogenesis. 2-Bromo-LSD D-Tartrate reverses the behavioral effects of chronic stress and increases active coping behaviors in mice.
DC80035 2-Bromo-5-Chloroterephthalic Acid 2-Bromo-5-Chloroterephthalic Acid (2-Bromo-5-chloroterephthalic acid) is a metal-organic framework (MOF).
DC80011 1-Nonadecanoin-2,3-acetyl 1-Nonadecanoin-2,3-acetyl is an acylglycerol.
DC80001 1-Heptanoyl-2,3-diacetyl 1-Heptanoyl-2,3-diacetyl is an acylglycerol.
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