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Zelpolib

  Cat. No.:  DC42609   Featured
Chemical Structure
701932-26-5
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More than 5000 active chemicals with high quality for research!
Field of application
Novel DNA polymerase inhibitor, inhibiting DNA replication in assays to assess global DNA synthesis or single-molecule bases by DNA fiber fluorography
Cas No.: 701932-26-5
Chemical Name: Zelpolib
Synonyms: Zelpolib;Methyl 2-(2-(3-(3,4-dihydroxyphenyl)propanoyl)hydrazine-1-carbothioamido)-5-phenylthiophene-3-carboxylate;STK457409;ST50849816;methyl 2-[({[3-(3,4-dihydroxyphenyl)propanoylamino]amino}thioxomethyl)amino]-5 -phenylthiophene-3-carboxylate;methyl 2-[({2-[3-(3,4-dihydroxyphenyl)propanoyl]hydrazinyl}carbonothioyl)amino]-5-phenylthiophene-3-carboxylate
SMILES: S1C(=C(C(=O)OC([H])([H])[H])C([H])=C1C1C([H])=C([H])C([H])=C([H])C=1[H])N([H])C(N([H])N([H])C(C([H])([H])C([H])([H])C1C([H])=C([H])C(=C(C=1[H])O[H])O[H])=O)=S
Formula: C22H21N3O5S2
M.Wt: 471.5492
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
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MSDS_26239_DC42609_701932-26-5
COA
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Cat. No. Product name Field of application
DC82301 IC-8 IC8 is an ionizable cationic lipid. It has been used in combination with other lipids for the formation of lipid nanoparticles (LNPs). Immunization with severe acute respiratory coronavirus 2 (SARS-CoV-2) spike glycoprotein mRNA in IC8- and manganese-containing LNPs induces IgG responses to SARS-CoV-2 Delta and Omicron variants in mice.1 Administration of mRNA encoding B7-H3 X CD3 bispecific T cell engaging (BiTE) antibodies in IC8-containing LNPs reduces tumor growth in MV4-11 and A375 mouse xenograft models.
DC75721 CL2A-SN38 (Govitecan) CL2A-SN38 is a SN38 derivative with a peptide-linker which can easily react with antibody to form an antibody-drug conjugate (ADC). CL2A-SN-38 is composed of a potent a DNA Topoisomerase I inhibitor SN-38 and a linker CL2A to make antibody drug conjugate (ADC). CL2A-SN-38 provides significant and specific antitumor effects against a range of human solid tumor types. CL2A is a noncleavable complicated PEG8- and triazole-containing PABC-peptide-mc linker. CL2A is cleavable through pH sensitivity, giving rise to bystander effect, and binds the antibody at a cysteine residue via a disulfide bond. .
DCC4995 Szu101 Novel TLR7 agonist via immune response induction and tumor microenvironment modulation
DCC3219 Malp-2 Toll-like receptor 2/6 (TLR-2/6) agonist, regulating Lcn2 gene, promoting collateral growth
DC72823 SU056 SU056 is an inhibitor of Y box binding protein 1 (YB-1) with IC50 of 1.73 μM in Sk0V3 cells.
DC72724 PTC258 PTC258 is a specific and orally active splicing modulator of Elongator complex protein 1 gene (ELP1). PTC258 increases the expression of ELP1 in vitro and in vivo. PTC258 is well tolerated in mouse model.
DC72507 VT-1598 tosylate VT-1598 tosylate is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 tosylate shows anti-fungal activity against C. auris.
DC72432 DSPE-N3 DSPE-N3 is a lipid. DSPE-N3 can be used for the research of various biochemical.
DC72429 DSPE-glutaric acid DSPE-glutaric acid is a lipid. DSPE-glutaric acid can be used for the research of various biochemical.
DC71975 TriGalNAc CBz TriGalNAc CBz is a GalNAc derivative and tri-GalNAc is an asialoglycoprotein receptor (ASGPR) ligand. TriGalNAc CBz can be used for mRNA drug delivery as well as lysosomal targeted chimerism (LYTAC) studies.
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