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Home > Inhibitors & Agonists > GPCR > Chemokine Receptor (CCR and CXCR)

Chemokine Receptor (CCR and CXCR)

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Cat. No. Product Name Field of Application Chemical Structure
DC11204 CCR6 inhibitor 35
CCR6 inhibitor 35 is a potent and selective CCR6 inhibitor with IC50 of 6.0 nM (hCCR6).
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DC11975 AZ 10397767
AZ10397767 is a potent, selective CXCR2 inhibitor that inhibits CXCL8 binding to CXCR2 with pIC50 of 9.0.
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DC11147 AZ084
AZ084 (AZ-084) is a potent, selective, allosteric, orally available CCR8 antagonist with Ki of 0.9 nM.
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DC11685 CCX-777
A small-molecule partial agonist of CXCR7 (ACKR3)..
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DC11687 (S)-CCX-777
A small-molecule partial agonist of CXCR7 (ACKR3)..
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DC11686 (R)-CCX-777
A small-molecule partial agonist of CXCR7 (ACKR3)..
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DC11698 α-NETA
A small molecule CMKLR1 antagonist that inhibits chemerin-stimulated β-arrestin2 association with CMKLR1 (EC50=9.7 nM).
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DC11977 SX-517
A potent, specific, noncompetitive dual CXCR1 and CXCR2 antagonist with IC50 of 38 nM (vs. CXCL1) and 36 nM (vs. CXCL8), respectively.
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DC11983 CX797
A potent, specfic CXCR2 antagonist that inhibits IL8 down-regulation of forskolin-induced cAMP with IC50 of 7.79 uM.
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DC11746 JNJ-27141491
A potent, selective, noncompetitive, orally active CCR2 antagonist with IC50 of 172 nM.
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DC11744 CCR2-RA-[R]
A potent, selective, allosteric CCR2 antagonist with IC50 of 103 nM..
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DC11745 BMS-22
A potent, selective, allosteric CCR2 antagonist with binding IC50 of 5.1 nM.
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DC11700 Chalcone 4 hydrate
A potent, selective inhibitor of CXCL12 binding to CXCR4 and CXCR7 with IC50 of 200 nM.
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DC11979 SB 332235
A potent, selective and competitive CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with pKi of 8.92.
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DC11976 SX-576
A potent, equipotent CXCR1 and CXCR2 antagonist with IC50 of 31 nM and 21 nM, respectively.
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DC11699 VUF11403
A potent CXCR7 (ACKR3) agonist..
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DC11743 BMS-681
A potent and orally bioavailable dual antagonist of CCR2 and CCR5 with binding IC50 of 0.7 nM and 2.4 nM, respectively.
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DC11981 CX4152
A novel potent, selective CXCR2 inhibitor with IC50 of 7.6 nM.
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DC11982 CX815
A novel potent, selective CXCR2 inhibitor with IC50 of 0.4 nM.
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