8-Amino-1-octanol (NH2-(CH2)7-COOH) is a PROTAC linker that can be used in the synthesis of PROTACs.

(Z)-9-Hexadecenyl acetate is a female sex pheromone isolated from 3-day-old female Mamestra configurata. (Z)-9-Hexadecenyl acetate can induce an electroantennographic response and attract 2-day-old male moths.

Pyrantel is an orally active anthelmintic and an agonist of the nicotinic acetylcholine receptor (nAChR). Pyrantel can cause spasmodic muscle paralysis in parasites. Pyrantel can be used in the study of parasitic infections such as ascariasis, hookworm infections, intestinal worms (pinworm infections), trichinosis and trichinosis.

cis-4-Decen-1-ol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Pentacosanoic acid is a 25-carbon long-chain saturated fatty acid. Pentacosanoic is a conjugate acid of a pentacosanoate.

(Z)-8-Dodecenyl acetate is an active compound.

(Z)-Tetradec-9-en-1-ol is an ester product.

16-Bromohexadecanoic acid is a PROTAC linker that can be used in the synthesis of PROTACs.

(Z)-11-Eicosen-1-ol is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Tetradecanal is for research use only, not for human or veterinary use.

(9Z,11E)-Prodlure ((9Z,11E)-Tetradecadien-1-yl acetate) is the main component of the sex pheromone of female Spodoptera littoralis.

16-Bromo-1-hexadecanol is a PROTAC linker that can be used in the synthesis of PROTACs.

Tert-butyl 12-bromododecanoate is a PROTAC linker that can be used in the synthesis of PROTACs.

SM-6.1 is a small molecule delivery vehicle developed by Arrowhead, targeting αvβ6, which selectively delivers therapeutic siRNA to lung epithelial cells and mediates durable gene silencing post-inhalation.

SYBR Green I is a sensitive dsDNA binding dye, which can be used for routine DNA detection in agarose and polyacrylamide gels.

pHrodo-NHS is an NHS ester of a pH-sensitive fluorescent dye. The NHS ester at its terminus can covalently conjugate with the amine groups of proteins or peptides, enabling stable labeling. This dye exhibits pH sensitivity, showing weak fluorescence in neutral or alkaline environments but significantly enhanced fluorescence in acidic conditions (pH 4–6), making it suitable for dynamically monitoring acidic processes.

MSC778 is an effective and orally active flap endonuclease 1 (FEN1) inhibitor with an IC50 of 3 nM and a KD of 2.9 nM. MSC778 exhibits 145-fold, 516-fold, and 65-fold selectivity over EXO1, GEN1, and XPG, respectively. MSC778 selectively kills BRCA2-deficient cells and potentiates the activity of Niraparib to induce tumor stasis in a BRCA2 KO DLD-1 mouse xenograft. MSC778 can be used in the research of colorectal cancer.

NC-TNP (noncationic thiourea lipids nanoparticles) could compress mRNA by strong hydrogen bonds interaction between thiourea groups of NC-TNP and the phosphate groups of mRNA. NC-TNP could escape the recycling pathway to inhibit the egress of internalized nanoparticles from the intracellular compartment to the extracellular milieu. NC-TNP-encapsulated mRNA shows higher gene transfection efficiency in vitro and in vivo than mRNA-LNP formulation. NC-TNP also shows spleen targeting delivery ability with higher accumulation ratio (spleen/liver), compared with traditional LNP.The C18 non-cationic thiourea lipid self-assembles into ~100 nm nanoparticles with neutral surface charge, utilizing strong hydrogen bonding between its thiourea groups and mRNA phosphate groups for efficient mRNA complexation. This delivery system demonstrates significantly enhanced EGFP expression efficiency—2.3-fold higher than standard C6/C12 formulations—in DC2.4, B16, and 4T1 cells, while sustaining luciferase activity for over 20 days post-subcutaneous injection. It exhibits exceptional stability, maintaining >94% mRNA integrity and <10% particle size variation after 30-day lyophilized storage. Importantly, the nanoparticles show pronounced spleen-targeting capability with 20-fold greater accumulation in the spleen versus liver, effectively activating twice the level of antigen-specific CD8⁺ T cells. Critically, the system avoids cationic lipid-associated toxicity, inducing no detectable IL-6/CXCL10 inflammation and causing no histopathological damage in cardiac or splenic tissues, thus establishing a novel high-efficacy, low-toxicity mRNA delivery platform.