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GPCR

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Cat. No. Product Name Field of Application Chemical Structure
DC4158 Tranabant (MK-0364)
Taranabant is a highly selective cannabinoid-1 (CB1) receptor inverse agonist.
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DCAPI1445 strontium ranelate
Strontium Ranelate is a bone metabolism modulator that inhibits bone resorption while maintaining bone formation. Commonly used as an antiosteoporotic.
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DC9422 ST-836 (hydrochloride)
ST-836 Hcl is a dopamine receptor ligand; Antiparkinsonian agent.
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DC9055 Sotalol HCl
Sotalol Hydrochloride is an adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
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DC9420 SKF-82958 (hydrobromide)
SKF 82958 hydrobromide is a D1/D5 receptor full agonist.
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DC9319 Setiptiline
Setiptiline(Org-8282) is a serotonin receptor antagonist.
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DC9320 Setiptiline (maleate)
Setiptiline is a serotonin receptor antagonist.
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DC11912 Seliforant
Seliforant (SENS-111, SENS111) is a novel potent, selective histamine H4 receptor antagonist..
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DC9410 SCH 527123
SCH-527123 is a potent antagonist of both CXCR1 and CXCR2 with IC50 of 42 nM and 3 nM, respectively.
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DC9409 SCH 546738
SCH 546738 is a novel, potent and non-competitive small molecule CXCR3 antagonist with Ki of 0.4 nM .
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DC9316 SB 271046 (Hydrochloride)
SB271046 Hcl is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9.
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DC8878 SB 242084
SB 242084 is a potent and selective antagonist of 5-HT2C receptor.
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DC10392 S1p receptor agonist 1
S1p receptor agonist 1 is an S1P receptor agonist extracted from patent WO 2015039587 A1, compound example 2.
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DC12250 RS 17053 hydrochloride (RS-17053)
RS 17053 hydrochloride is a potent and selective α1A adrenoceptor antagonist, with a pKi value of 9.1 in native cell membrane and a pA2 value of 9.8 in functional assays.
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DCAPI1584 Roxatidine Acetate Hydrochloride
Roxatidine Acetate Hydrochloride is a histamine H2-receptor antagonist used in ulcer treatment. This compound has been found to inhibit platelet function in vitro.
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DCAPI1466 Rizatriptan Benzoate
Rizatriptan Benzoate is a selective serotonin 5-HTID receptor agonist which is structurally derived from tryptamine.
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DC7828 Ramelteon
Ramelteon is a novel melatonin receptor agonist for human MT1 and MT2 receptors and chick forebrain melatonin receptors with Ki of 14 pM, 112 pM and 23.1 pM, respectively.
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DC11138 Guanabenz acetate
R15A inhibitor.
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DC8289 Prucalopride succinate
Prucalopride succinate is a selective, high affinity 5-HT4 receptor agonist with pKi of 8.6/8.1 for 5-HT4a/4b.
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DC10260 Prochlorperazine
Prochlorperazine is a dopamine (D2) receptor antagonist that belongs to the phenothiazine class of antipsychotic agents. It is also a highly potent typical antipsychotic.
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DC3151 Pramipexole dihydrochloride
Pramipexole is a partial/full D2S, D2L, D3, D4, receptor agonist with a Ki of 3.9, 2.2, 0.5, 5.1 nM.
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DC8970 Pramipexole Base
Pramipexole is a dopamine agonist of the non-ergoline class indicated for treating Parkinson's disease (PD) and restless legs syndrome (RLS).
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DC7492 SB 258585 hydrochloride
Potent and selective 5-HT6 receptor antagonist (pKi = 8.6).
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DC12183 Phenylbiguanide (N-Phenylbiguanide; PBG; 1-Phenylbiguanide)
Phenylbiguanide is a 5-HT3 receptor selective agonist with an EC50 of 3.0±0.1 μM.
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DC9101 Phentolamine mesilate
Phentolamine Mesylate is a nonselective alpha-adrenergic antagonist.
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DC9083 Pheniramine Maleate
Pheniramine Maleate ia an antihistamine and vasoconstrictor.
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DC11116 PF-06827443
PF-06827443 (PF06827443) is a potent, orally bioavailable, and CNS-penetrant M1-selective positive allosteric modulator (PAM) with EC50 of 47 nM, shows no activity against M2-M5 at 10 uM.
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DC11111 PF-06764427
PF-06764427 (PF06764427) is a potent, selective M1 muscarinic acetylcholine receptor (mAChR) positive allosteric modulator with EC50 of 55 nM, has no measurable agonist or PAM activity at the M2-M5 receptors at 10 uM.
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DC11665 PF-00446687
PF-00446687(PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.
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DC11664 PF-00446687 hydrochloride
PF-00446687 hydrochloride (PF-446687) is a potent, selective melanocortin-4 receptor (MC4R) agonist with EC50 of 12 nM.
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