A small molecule iron transport inhibitor that promotes degradation of transferrin receptor-1 in vitro and in vivo, through a nystatin-sensitive lipid raft pathway.

A small molecule inhibitor of α4 integrin-dependent cell migration (IC50=0.5 uM, on the motility of Jurkat T cells) that functions by interacting with γ-parvin.

A small molecule inhibitor of Staphylococcus aureus sortase with IC50 of 9.3 uM.

A small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 90 nM.

A small molecule inhibitor of RNA-binding protein Hu protein R (HuR) that interferes the HuR homodimerization with Kd of 7 nM.

A small molecule inhibitor of RNA binding protein Lin28 that blocks the Lin28/let-7 interaction, rescues let-7 processing and function in Lin28-expressing cancer cells.

A small molecule inhibitor of RAD51-mediated homologous recombination.

A small molecule inhibitor of polyglutamine (polyQ) aggregation in Huntington's disease neurons.

A small molecule inhibitor of NEMO (IKKγ)-ubiquitin binding with EC50 of 9.3 uM, directly binds to NEMO with Kd of 2.14 uM.

A small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 5.3 uM in ELISA assay.

A small molecule inhibitor of MDM2-p53 protein-protein interaction with IC50 of 16 uM..

A small molecule inhibitor of HIV-1 entry via the CCR5 coreceptor.

A small molecule inhibitor of HECT-type ubiquitin ligase with IC50 of 6.8/6.3/6.9 uM for Smurf2/Nedd4/WWP1, respectively.

A small molecule inhibitor of HDM2-p53 interaction with FP IC50 of 0.7 uM.

A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=3.4 uM) and disrupts GEF-Ras interaction.

A small molecule inhibitor of guanine nucleotide exchange factor (GEF) catalytic activity that binds to SOS1 (Kd=14.7 uM) and disrupts GEF-Ras interaction.

A small molecule inhibitor of Ezrin with Kd of 5.85 uM.

A small molecule Grb2 SH2 domain binding antagonist that synergistically enhances inhibition of K562 leukemia cell proliferation by imatinib (CI=0.774).

A small molecule Cu complexing ligand used for atom transfer radical polymerization (ATRP).

A small molecule cognitive enhancer that potentiates acetylcholine-mediated facilitation of inhibitory synaptic transmission in the hippocampal neurons.

A small molecule CMKLR1 antagonist that inhibits chemerin-stimulated β-arrestin2 association with CMKLR1 (EC50=9.7 nM).

A small molecule CD4-mimetic that binds gp120 and blocks CD4 binding, inhibits HIV-1 entry with IC50 of 86.9 uM..

A small molecule autophagy enhancer that specificly inhibits myotubularin-related phosphatase MTMR14.

A small molecule autophagy enhancer that induces autophagy independently of rapamycin in mammalian cells and enhances the clearance of autophagy substrates such as mutant huntingtin and A53T alpha-synuclein.

A small molecule ANXA7 GTPase activity inhibitor, induces mouse ESCs differentiation to VECs.

A small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that binds to the APC preferentially suppresses APC/C(Cdc20) rather than APC/C(Cdh1).

A small molecule allosteric inhibitor of TREK channels with IC50 of 6.5, 4.4 and 15.7 uM for TREK-1, TREK-2 and TRAAK, respectively..

A small molecule allosteric inhibitor of TREK channels with IC50 of 5.0, 5.0 and 11.8 uM for TREK-1, TREK-2 and TRAAK, respectively..

A small molecule allosteric inhibitor of TREK channels with IC50 of 3.8, 1.7 and 10.3 uM for TREK-1, TREK-2 and TRAAK, respectively..

A small molecule activator of S. aureus HssRS (heme sensor system) that induces endogenous heme biosynthesis by perturbing central metabolism.