Novel highly specific, potent, orally bioavailable MKP5 inhibitor

Novel potent and selective MKK3/6 inhibitor

Prodrug of raltegravir with enhanced colonic absorption

Novel agonist of G-protein coupled receptor 40 (GPR40)

Novel liver-targeting inhibitor of stearoyl-CoA desaturase (SCD)

Novel bombesin receptor subtype-3 (BRS-3) modulator

Novel potent muscarinic acetylcholine receptor 4 (M4) positive allosteric modulator (PAM)

Novel nonpeptide bombesin receptor subtype-3 agonist

Novel Selective Androgen Receptor Modulator (SARM)

Potent and selective human type-1 5alpha-reductase inhibitor

Potent TRPV1 antagonist

Novel renin inhibitor

Novel Macrocyclic Inhibitor of Hepatitis C Virus NS3/4A Protease with Improved Preclinical Plasma Exposure

Selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor

Selective 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor

Potent and Selective 5-Lipoxygenase Inhibitor

Novel Dipeptidyl peptidase IV (DPP-4) inhibitor, improving neovascularization by increasing both the number of circulating endothelial progenitor cells and endothelial nitric oxide synthetase expression

The class III antiarrhythmic agent, blocking HERG, a human cardiac delayed rectifier K+ channel

Novel potent, orally active and selective agonist of the melanocortin receptor 4 (MC4R)

Potent and selective PDE4 inhibitor

Specific inhibitor of the cellular inosine-5-monophosphate dehydrogenase (IMPDH); Immunosuppressive agent

Antineoplastic DNA alkylating agent

Novel selective fluorescent H2O2 probe, tracking the mitochondria of live biological specimens and responds to local fluxes of hydrogen peroxide (H2O2) by a turn-on fluorescence enhancement

Novel potent antiproliferative mitochondria-targeted OXPHOS inhibitor (IC50=38 nM) in MiaPaCa-2 cells, being more effective than other inhibitors of OXPHOS in MiaPaCa-2 and U87MG cells

Novel mitochondrial-targeted pan-APT inhibitor

Radiation Mitigator, reducing lipid hydroperoxides and preventing apoptotic cell death

Fluorescent probe for measuring the activity levels of erasers of S-palmitoylation, acyl-protein thioesterases (APTs), within mitochondria of live cells

Sensitive and specific Raman probe for live cell imaging of mitochondria

The first small molecule inhibitor of Mitf-E-box DNA binding with depigmenting activity

Novel inhibitor of AMA1-RON2 interaction, blocking merozoite invasion from schizont-infected RBCs; Antidepressant; Acetylcholinesterase inhibitor