Novel antimalarial agent with increased efficacy against one or more pfatp4 mutated clones

Novel MEP pathway-targeting antimalarial agent

Novel potent Plasmodium lactate transporter PfFNT

Novel antimalarial agent against asexual stages of P. falciparum

The first small-molecule anti-plasmodial agent, disrupting rosetting, simultaneously restoring microcirculation and reduce parasite load

Novel inhibitor of lanosterol-14-alpha-demethylase (TcCyp51)

Highly water-soluble antifibrotic agent, reducing the profibrotic phenotype induced in vitro in primary human fibroblasts and ameliorating bleomycin-induced pulmonary fibrosis in vivo

Novel Mmpl3 inhibitor, indirectly blocking translocation of Trehalose Monomycolates across the IM

Negative allosteric modulator (NAM) ligand for the mGlu5 receptor

Novel highly potent and selective MMP13 inhibitor

Novel potent and selective HDAC8 inhibitor

Novel potent and selective HDAC8 inhibitor

Novel potent and selective HDAC8 inhibitor

Novel potent IDO1 inhibitor, showing low cytotoxicity and higher selectivity for IDO1 over TDO enzyme

Novel potent and selective MALT-1 protease inhibitor, showing improved solubility and permeability in comparison with MLT-748

Potent agonist of TRPML channels specifically activating lysosomal ML1 currents

Novel inhibitor of human cytomegalovirus (HCMV) infection

Novel dual JAK/Src kinase inhibitor, suppressing growth of diverse cancer cells

Potent inhibitor of STAT3 and Akt signaling

Novel Inhibitor of Human Cytomegalovirus

Novel potent inhibitor of EBOV infection

Potent and selective mixed-type inhibitor of human epithelial 15-lipoxygenase-2 (15-LOX-2)

Potent and selective competitive inhibitor of human epithelial 15-lipoxygenase-2 (15-LOX-2)

Novel selective and potent inhibitor of recombinant h12/15-LOX and cellular mouse 12/15-LOX (m12/15-LOX)

Second generation 5-LO inhibitor, blocking the production of leukotrienes

Novel potent DNA binding agent, stabilizing topoisomerase-dependent cleavage, demonstrating exceptional efficacy against a number of murine and human tumor models

Novel IKK2 inhibitor, decreasing NF-κB activation and down-regulating the expression of a number of inflammatory proteins

Selective inhibitor of Myosin Light Chain Kinase (MLCK)

Novel Inhibitor of Scavenger Receptor BI-mediated Lipid Uptake

Novel endoplasmic reticulum proteostasis modulator, enhancing insulin production in pancreatic β cells, inhibiting the UPR, alleviating ER stress and protein aggregation, improving intracellular insulin levels and insulin secretion