Novel main protease (Mpro) inhibitor, inhibiting MHV-A29, HCoV-229E, FOPV replication, and SARS-CoV-2 viral cell entry

Specific estrogen receptor α (ERα) antagonist

Potent and selective COX-2 inhibitor

Novel selective class IIb histone deacetylase inhibitor (HDACi), dose-dependently decreasing the viability of Acanthamoeba trophozoites

Novel anti-cancer agent, being more potent and safer than conventional indomethacin

Novel potent and selective microsomal prostaglandin E synthase-1 (mPGES-1) inhibitor

Novel mixed kappa-delta opioid receptor agonist with anti-cocaine properties and reduced side-effects in rats

Potent and Specific PDE10A inhibitor

Natural antibacterial, antileishmanial, and antifungal agent

Potent dopamine antagonist with high affinity to the D2, D3, and D4 receptors, and with moderate affinity for the 5-HT2 receptors

Natural analogue of (-)-gambogic acid acting as a potent inhibitor of global predominant MRSA USA300

Natural potent antioxidant agent

Novel iminosugar, downregulatiing the interferon γ receptor by dengue virus

Natural antioxidant and antidiabetic agent

Novel inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity

Cell-permeable superoxide dismutase (SOD) mimetic

Potent and selective Mnk2 inhibitor

Novel highly potent and selective MNK1/2 kinases inhibitor

Novel anticancer agent, inducing apoptosis, inhibiting migration and invasion

First-in-class acetyl-CoA synthetase (AcAS) inhibitor, showong single digit nanomolar in vitro activity against P. falciparum and P. vivax clinical isolates, and potently blocking P. falciparum transmission to Anopheles mosquitoes

Novel potent broad antiparasitic agent against intracellular Leishmania amastigotes, Trypanosoma brucei, and Plasmodium falciparum

Novel potent inhibitor of P. falciparum asexual blood stages, inhibiting heme detoxification

Selective allosteric inhibitor of Plasmodium Kinesin-5

Novel antimalarial agent, targeting P. falciparum farnesyltransferase PfFT, showing remarkable growth inhibition with EC50 value of 0.4 µM and presenting good selectivity index (SI > 250)

Novel antimalarial agent against Plasmodium falciparum

Novel inhibitor of Plasmodium falciparum, killing both blood- and sexual-stage P. falciparum parasites

Novel antimalarial agent with increased efficacy against one or more pfatp4 mutated clones

Novel antischistosomal agent against chronic S. mansoni infection

Novel antischistosomal agent against chronic S. mansoni infection

Novel Inhibitor of Plasmodium falciparum