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Orexin Receptor

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Cat. No. Product Name Field of Application Chemical Structure
DC42501 Orexin receptor antagonist 2
Orexin receptor antagonist 2 (compound 30) is a potent orexin receptor antagonist with pKis of 7.69 and 9.78. Orexin receptor antagonist 2 has the potential for the research of insomnia.
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DC41792 OXA(17-33) TFA
OXA(17-33) TFA is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) TFA shows a ~23-fold selectivity for the OX1 (EC50=8.29 nM) over OX2 (187 nM).
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DC41791 OXA(17-33)
OXA(17-33) is a potent and selective orexin-1 receptor (OX1) agonist. OXA(17-33) shows a ~23-fold selectivity for the OX1 (EC50=8.29 nM) over OX2 (187 nM).
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DC41790 [Ala11,D-Leu15]-Orexin B(human) TFA
[Ala11,D-Leu15]-Orexin B(human) TFA is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) TFA shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (52 nM).
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DC41789 [Ala11,D-Leu15]-Orexin B(human)
[Ala11,D-Leu15]-Orexin B(human) is a potent and selective orexin-2 receptor (OX2) agonist. [Ala11,D-Leu15]-Orexin B(human) shows a 400-fold selectivity for the OX2 (EC50=0.13 nM) over OX1 (52 nM).
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DC41022 Orexin receptor antagonist 3
Orexin receptor antagonist 3 (example 216) is an orexin receptor antagonist, which is extracted from the patent WO2011050198A1.
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DC7646 MK3697
MK-3697 is a third insomnia drug, currently being developed by Merck. MK-3697 is a potent and selective Orexin receptor antagonist with Ki = 0.95 nM.
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