Many natural and synthetic molecules contain aldehyde or ketone carbonyl groups. These carbonyls react with hydrazides with the formation of hydrazones. The reaction is spontaneous at pH values around neutral, and the resulting hydrazones are very stable. Compounds containing 1,2-diol function, like sugars, can be oxidized with sodium periodate with the formation of carbonyl compounds for the subsequent modification with hydrazides. This is an efficient method for the labeling of glycoproteins (like antibodies), and polysaccharides. FAM hydrazide is a hydrazide label for the attachment of fluorescein, a bright dye for 488 nm channel, to carbonyl compounds

A reactive dye with a maleimide group for the labeling of thiol groups of proteins and other biomolecules, an analog of Cy7? maleimide. Sulfo-Cyanine7 is a near infrared fluorophore which is hydrophilic and contains a rigidizing ring in its heptamethine chain that improves its photophysical properties. A great dye for various applications, including NIR imaging.

BDP R6G is a borondipyrromethene fluorophore whose absorption and emission spectra match those of rhodamine 6G (R6G) dye. Thiol labeling is often an option of choice for the modification of proteins. Limited number of cysteine residues in proteins allow for more site-specific labeling than NHS ester labeling of amine groups, which are encountered in large number in many proteins. This maleimide is a thiol reactive dye. Please refer to our recommended labeling protocol to achieve modification of your protein with this reagent.

BDP 630/650 is a far red emitting borondipyrromethene based fluorophore for the Cyanine5 channel. Because of its relatively long lifetime of the excited state, this dye is particularly useful for fluorescence lifetime related measurements. The reactive maleimide moiety allows to attach the dye to thiol groups in biomolecules, especially proteins and peptides.

BDP 630/650 azide is a bright and photostable dye azide for the far red region of the spectrum, for labeling using Click chemistry. This dye possesses a relatively long lifetime of the excited state, and can therefore be used for fluorescence polarization experiments.

BDP 581/591 is a bright and versatile fluorophore. It has a high brightness, significant two photon cross-section, and relatively long fluorescence lifetime. The dye reacts with reactive oxygen species (ROS) with the change of its fluorescence. It can be therefore used for intracellular monitoring of ROS. It can be used for the conjugation with both small molecules and biomolecules to construct tracers for fluorescence polarization assays and microscopy probes.

BDP TR is a borondipyrromethene dye which has absorption and emission wavelengths close to Texas Red (ROX) dye. The fluorophore is bright, moderately hydrophobic, and has low molecular weight. An extra linker based on aminocaproic acid (C6) provide better separation between the dye, and the biomolecule. The NHS ester function can be used for the conjugation with proteins, peptides, and other molecules possessing amine group.

Kojibiose is a disaccharide. It is a product of the caramelization of glucose. It is also present in honey.

2-Acetylpyrazine is a pyrazine and a ketone. It is a yellow-brown powder at room temperature.

Deiodoamiodarone is an intermediate of amiodarone, which is an α/β-adrenergic receptor antagonist and coronary vasodilator.

Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.

Phenylethyl isothiocyanate is an HDAC inhibitor potentially for the treatment of benign prostatic hypertrophy.

Oxymetazoline is a selective α1 adrenergic receptor agonist and α2 adrenergic receptor partial agonist. It is a topical decongestant, used in the form of oxymetazoline hydrochloride in products such as Afrin, Dristan, Nasivin, Nezeril, Nostrilla, Logicin, Vicks Sinex, Visine L.R., Sudafed OM, Zicam, SinuFrin and Mucinex Sinus-Max. It was developed from xylometazoline at E. Merck Darmstadt by Fruhstorfer in 1961. Oxymetazoline is generally available as a nasal spray.

Metribuzin is a triazine herbicide.

JWH-022 is a cannabimimetic indole that is structurally related to JWH 018, a mildly selective agonist of the peripheral cannabinoid (CB2) receptor.

JWH 072 is a synthetic cannabinoid (CB) that displays a higher affinity for the peripheral CB2 receptor (Ki = 170 nM) than the central CB1 receptor (Ki = 1,050 nM). The physiological and toxicological properties of this compound are not known.

JS-K is a Nitric oxide donor; antiproliferative.

D&C Red No. 8 is a dye.

Amarogentin displays immunomodulatory effects in human Mast Cells and Keratinocytes.

Cauloside C, also known as Hederoside D2, is a triterpenoid saponin that induces potassium release and hemolysis in mouse erythrocytes in a pH-dependent manner. Hederoside D2 is cytotoxic to N1E-115 neuroblastoma cells at low pH. It induces proliferation of human embryonic fibroblasts in acidic medium, an effect that can be blocked by the calcium channel blockers verapamil, diltiazem, and nitrendipine.

AI3-17602 is a biochemical.

Benzyl lactate is a biochemical.

Myristyl glycol is a type of glycol.

Tafluprost acid is a selective agonist at the prostaglandin F receptor, increasing outflow of aqueous fluid from the eyes and thus lowering intraocular pressure.

IDO-IN-3 is an inhibitor of indoleamine-2,3-dioxygenase 1.

Mahanimbine is a major carbazole alkaloid from Murraya koenigii (curry leaves) that may alleviate development of HFD-induced metabolic alterations.

WEHI-539 has high affinity (IC50=1.1 nM) and selectivity for BCL-XL and potently kills cells by selectively antagonizing its prosurvival activity. It has more than a 400-fold higher affinity for BCL-XL versus other prosurvival BCL-2 family members.

3-hydroxy Darifenacin is a metabolite of darifenacin. It is an antagonist of M1-5 muscarinic receptors.

Feglymycin is a 13-amino acid peptide that has antibacterial and antiviral activities. It is active against Gram-positive bacteria and inhibits HIV viral replication.

CAY10737 is a turn-on fluorescent probe for the detection of carbon monoxide (CO). It is selective for CO over a variety of anions, amino acids, amines, biothiols, and reactive species. In the presence of palladium (Pd) and CO, CAY10737 undergoes the Pd0-mediated Tsuji-Trost reaction to release a fluorescent compound that has absorption and emission maxima of 678/714 nm, respectively. This fluorescence can be used to detect CO production in vitro and in vivo.