AM-211 sodium is a novel and potent antagonist of the prostaglandin D2 receptor type 2. AM-211 is active in animal models of allergic inflammation. AM211 has high affinity for human, mouse, rat, and guinea pig DP2 and it shows selectivity over other prostanoid receptors and enzymes. AM211 exhibits good oral bioavailability in rats and dogs and dose-dependently inhibits 13,14-dihydro-15-keto-PGD(2)-induced leukocytosis in a guinea pig pharmacodynamic assay.

Amino-PEG4-t-Boc-hydrazide is a PEG derivative containing an amino group and a Boc-protected hydrazide. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The Boc can be deprotected under mild acidic conditions to form a reactive hydrazide, which can then be coupled with various carbonyl groups. PEG Linkers may be useful in the development of antibody drug conjugates.

Amino-PEG2-(CH2)3CO2H is a PEG derivative containing an amino group with a terminal carboxylic acid. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. PEG Linkers may be useful in the development of antibody drug conjugates and drug delivery methods.

Mal-amido-PEG4-acid is a PEG derivative containing a maleimide group and a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol.

m-PEG4-Mal is a PEG derivative containing a maleimide group. The maleimide group will react with a thiol group to form a covalent bond, enabling the connection of biomolecule with a thiol. The hydrophilic PEG spacer increases solubility in aqueous media.

t-Boc-N-Amido-PEG6-propargyl is a PEG derivative containing a propargyl group and Boc-protected amino group. The propargyl group can be reacted with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Oxethazaine is a surface anesthetic used mainly orally in chronic gastritis & heartburn to analgize the gastric mucosa.

N-methyl-N-(t-Boc)-PEG4-acid is a Boc PEG Linker. PEG Linkers may be useful in the development of antibody drug conjugates.

Bromoacetamido-PEG4-NHS ester is a PEG derivative containing a bromide group and an NHS ester. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The NHS ester can be used to label the primary amines (-NH2) of proteins, amine-modified oligonucleotides, and other amine-containing molecules.

t-Boc-N-amido-PEG1-NHS ester is a Boc-protected PEG linker. The Boc group can be deprotected under acidic conditions to generate a free amine group. PEG Linkers may be useful in the development of antibody drug conjugates (ADCs).

Amino-PEG1-t-butyl ester is a PEG derivative containing an amino group with a t-butyl protected carboxyl group. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. PEG Linkers may be useful in the development of antibody drug conjugates and drug delivery methods.

Benzyl-PEG2-azide is a PEG Linker. PEG Linkers may be useful in the development of antibody drug conjugates.

NH-bis(PEG3-azide) is a PEG derivative containing an amino group with two azide groups. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls. The azide groups enable PEGylation via Click Chemistry.

N-Boc-N-bis(PEG3-azide) is a branched PEG derivative with two terminal azide groups and a Boc protected amino group. The azide groups enable PEGylation via Click Chemistry. The protected amine can be deprotected by acidic conditions.

Loratadine specified impurity F is a fluorinated analog of Loratadine, which is a nonsedating-type histamine H1-receptor.

S-Fcme is a multidrug resistance transporter activator. It acts by stimulating the multidrug resistance transporter ATPase activity and competing for drug binding.

CDK4-IN-1 is a selective inhibitor of cyclin-dependent kinase 4.

Pleuromulin is an antibiotic that derives from a class of antibacterials with different mechanisms of action from clinically used antibacterials. This is of interest due to the rapid onset of resistance to most antibacterial drugs. It has been shown that there is rarely cross-resistance between pleuromutilin derivatives and other antimicrobial agents.

Ro 41-0960 is a reversible and orally-active COMT-inhibitor.

Spacer phosphoramidite 18 (hexaethylene glycol phosphoramidite) is an amidite reagent for oligonucleotide synthesis. It provides a long hydrophilic linker that can be used for the synthesis of Scorpion-type qPCR probes, for spacing biotin from oligo strand, and for other applications requiring spatial separation of modifier and oligo

m-PEG9-bromide is a PEG derivative. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

m-PEG6-bromide is a PEG derivative. The bromide (Br) is a very good leaving group for nucleophilic substitution reactions. The hydrophilic PEG spacer increases solubility in aqueous media.

MS-1020 is a JAK3 and STAT3 inhibitor. MS-1020 potently inhibits persistently-active STAT3 in a cell type-specific manner. MS-1020 selectively blocks constitutively-active JAK3 and consistently suppressed interleukin-2-induced JAK3/STAT5 signalling.

T-Butyl 1,3-dihydroxypropan-2-ylcarbamate is a PEG Linker. PEG Linkers may be useful in the development of antibody drug conjugates.

Azido-PEG3-CH2CO2Me is a crosslinker containing an azide group a methyl ester. The azide group enables Click Chemistry. The hydrophilic PEG spacer increases solubility in aqueous media.

Biotin-PEG3-NHS ester is PEG derivative containing a biotin group and an NHS ester group. The NHS group reacts specifically and efficiently with lysine and N-terminal amino groups at pH 7-9 to form stable amide bonds. PEG Linkers may be useful in the development of antibody drug conjugates.

Ro-31-7549 Monohydrate is a cell permeable, reversible, selective protein kinase C (PKC) inhibitor.

Tr-PEG5 is a PEG derivative.

m-PEG12-acid is a PEG derivative containing a terminal carboxylic acid. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. The hydrophilic PEG spacer increases solubility in aqueous media.

Ticagrelor metabolite M5, also known as AR-C133913XX, is a metabolite of Ticagrelor which is the first reversible oral P2Y12 receptor antagonist. Ticagrelor provides faster and more consistent ADP-receptor inhibition than Clopidogrel. Ticagrelor is used in the treatment of acute coronary syndromes (ACS).