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Home > PROTACs > E3 Ligase Ligand

Pomalidomide-C2-NH2(E3 ligase Ligand 17)

  Cat. No.:  DC50061   Featured
Chemical Structure
1957235-66-3
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Field of application
E3 ligase Ligand 17 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
Chemicals PropertiesBiological activity COA & MSDSRelated productsDatasheet
Cas No.: 1957235-66-3
Chemical Name: Pomalidomide-C2-NH2(E3 ligase Ligand 17)
Synonyms: Pomalidomide-C2-NH2 (hydrochloride);4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl;4-((2-Aminoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
SMILES: Cl[H].O=C1C2C(=C([H])C([H])=C([H])C=2C(N1C1([H])C(N([H])C(C([H])([H])C1([H])[H])=O)=O)=O)N([H])C([H])([H])C([H])([H])N([H])[H]
Formula: C15H17ClN4O4
M.Wt: 352.772882223129
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC86101 VH032-cyclopropane-F E3 ligase Ligand 19 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 19 can be connected to the ligand for protein (e.g., SMARCA BD ligand) by a linker to form PROTACs (e.g., PROTAC 1). PROTAC 1 is a partial degrader of SMARCA2 and SMARCA4[1]
DC51007 Lenalidomide-5-aminomethyl hydrochloride Lenalidomide-5-aminomethyl hydrochloride is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-5-aminomethyl hydrochloride can be connected to the ligand for protein by a linker to form PROTAC
DC51006 Lenalidomide-4-OH A Novel PROTACs building block.
DC71103 Pomalidomide-PEG4-COOH Pomalidomide-PEG4-COOH is a E3 ligase ligand-linker conjugate. Pomalidomide-PEG4-COOH contains the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology (extracted from patent WO2017184995A1).
DC47216 Thalidomide-5,6-F Thalidomide-5,6-F is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5,6-F can be connected to the ligand for protein by a linker to form PROTACs.
DC41134 Thalidomide-5-OH Thalidomide-5-OH is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-OH can be connected to the ligand for protein by a linker to form PROTACs.
DC12028 MDK7526(Protein degrader 1) MDK7526, also known as VHL Ligand 1; Protein degrader 1, is a potent and selective protein degrader.
DC11571 E3 Ligase Ligand 3 E3 ligase Ligand 3 is a ligand of E3 ligase, used in PROTAC technology.
DC50061 Pomalidomide-C2-NH2(E3 ligase Ligand 17) E3 ligase Ligand 17 is a ligand for E3 ubiquitin ligase. E3 ligase Ligand 17 can be connected to the ligand for protein by a linker to form PROTACs or SNIPERs. PROTACs are inducers of ubiquitination-mediated degradation of cancer-promoting proteins[1].
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